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==Structural basis for TSLP antagonism by the therapeutic antibody Tezepelumab (MEDI9929 / AMG-157)==
==Structural basis for TSLP antagonism by the therapeutic antibody Tezepelumab (MEDI9929 / AMG-157)==
<StructureSection load='5j13' size='340' side='right' caption='[[5j13]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5j13' size='340' side='right'caption='[[5j13]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5j13]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J13 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5j13]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J13 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.298&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j13 OCA], [http://pdbe.org/5j13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j13 RCSB], [http://www.ebi.ac.uk/pdbsum/5j13 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j13 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j13 OCA], [https://pdbe.org/5j13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j13 RCSB], [https://www.ebi.ac.uk/pdbsum/5j13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j13 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TSLP_HUMAN TSLP_HUMAN]] Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.<ref>PMID:11418668</ref> <ref>PMID:11480573</ref> <ref>PMID:17242164</ref>  Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.<ref>PMID:24850429</ref>
[https://www.uniprot.org/uniprot/TSLP_HUMAN TSLP_HUMAN] Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.<ref>PMID:11418668</ref> <ref>PMID:11480573</ref> <ref>PMID:17242164</ref>  Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.<ref>PMID:24850429</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Savvides, S N]]
[[Category: Homo sapiens]]
[[Category: Verstraete, K]]
[[Category: Large Structures]]
[[Category: Cytokine inflammation tslp antibody]]
[[Category: Savvides SN]]
[[Category: Immune system]]
[[Category: Verstraete K]]