5ul4: Difference between revisions
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==Structure of Cobalamin-dependent S-adenosylmethionine radical enzyme OxsB with aqua-cobalamin and S-adenosylmethionine bound== | ==Structure of Cobalamin-dependent S-adenosylmethionine radical enzyme OxsB with aqua-cobalamin and S-adenosylmethionine bound== | ||
<StructureSection load='5ul4' size='340' side='right' caption='[[5ul4]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='5ul4' size='340' side='right'caption='[[5ul4]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ul4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UL4 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5ul4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UL4 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ul4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ul4 OCA], [https://pdbe.org/5ul4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ul4 RCSB], [https://www.ebi.ac.uk/pdbsum/5ul4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ul4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/OXSB_PRIMG OXSB_PRIMG] Isomerase involved in the biosynthesis of oxetanocin A (OXT-A), a nucleoside analog with antitumor, antiviral and antibacterial properties (PubMed:28346939, PubMed:33560833). Catalyzes an oxidative ring contraction of dAMP, forming an oxetane aldehyde (PubMed:28346939, PubMed:33560833). In addition, shows methyltransferase activity in vitro and is able to catalyze the radical mediated, stereoselective C2'-methylation of dAMP to form methylated 2'-dAMP (PubMed:33560833, PubMed:36719327). Also catalyzes the demethylation of S-adenosyl-L-methionine (SAM) to S-adenosyl-L-homocysteine (SAH) (PubMed:33560833).<ref>PMID:28346939</ref> <ref>PMID:33560833</ref> <ref>PMID:36719327</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Priestia megaterium]] | ||
[[Category: | [[Category: Bridwell-Rabb J]] | ||
[[Category: | [[Category: Drennan CL]] | ||
Latest revision as of 12:35, 13 August 2026
Structure of Cobalamin-dependent S-adenosylmethionine radical enzyme OxsB with aqua-cobalamin and S-adenosylmethionine bound
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