Dual specificity phosphatase: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
Michal Harel (talk | contribs)
32,838 edits
No edit summary
Michal Harel (talk | contribs)
32,838 edits
No edit summary
 
(8 intermediate revisions by 3 users not shown)
Line 1: Line 1:
<StructureSection load='1ohe' size='350' side='right' scene='44/444621/Cv/1' caption='Human Cdc14B2 core domain (cyan) complex with tripeptide (green) and acetyl (PDB code [[1ohe]]).'>
<StructureSection load='' size='350' side='right' scene='44/444621/Cv/1' caption='Human Cdc14B2 core domain (cyan) complex with tripeptide (green) and acetyl (PDB code [[1ohe]]).'>


== Function ==
== Function ==


'''Dual specificity phosphatase''' (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues.  There are several DUSP enzymes in mammals sharing a common catalytic mechanism.  The DUSP include:<br />
'''Dual specificity phosphatase''' or '''Dual specificity protein phosphatase''' (DUSP) is a phosphatase which dephosphorylates phosphotyrosine, phosphoserine or phosphothreonine residues<ref>PMID:19228121</ref>.  There are several DUSP enzymes in mammals sharing a common catalytic mechanism.  The DUSP include:<br />
• '''Slingshot phosphatase'''<ref>PMID:17848544</ref><br />
• '''Slingshot phosphatase'''<ref>PMID:17848544</ref><br />
• '''Phosphatase of regenerating liver''' (PRL)<ref>PMID:24030100</ref><br />
• '''Phosphatase of regenerating liver''' (PRL)<ref>PMID:24030100</ref><br />
Line 24: Line 24:
== Structural highlights ==
== Structural highlights ==


<scene name='44/444621/Cv/5'>Tripeptide binding site</scene> in human Cdc14B2 (PDB code [[1ohe]]).<ref>PMID:12853468</ref>
<scene name='44/444621/Cv/6'>Tripeptide binding site</scene> in human Cdc14B2 (PDB code [[1ohe]]).<ref>PMID:12853468</ref>
</StructureSection>
 
==3D structures of dual specificity phosphatase==
==3D structures of dual specificity phosphatase==
[[Dual specificity phosphatase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Slingshot phosphatase (SSH)
 
**[[2nt2]]  – hSSH-2L catalytic domain - human<br />
 
*Phosphatase of regenerating liver (PRL)
 
**[[1xm2]]  – hPRL-1 (mutant)<br />
**[[1zck]], [[1x24]]  – rPRL-1 - rat<br />
**[[1zcl]] – rPRL-1 (mutant)<br />
**[[1r6h]], [[1v3a]], [[2mbc]]  – hPRL-3 - NMR<br />
 
*Cdc14
 
**[[1ohc]], [[1ohd]]  – hCdc14B2 core domain <br />
**[[1ohe]]  – hCdc14B2 core domain + peptide<br />
 
*Cdc25
 
**[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]]  – hCdc25B catalytic domain <br />
**[[2a2k]], [[2ifd]], [[2ifv]]  – hCdc25B catalytic domain (mutant)<br />
 
*Phosphoinositide phosphatase PTEN
 
**[[1d5r]], [[5bzz]], [[5bzx]], [[5bug]] – hPTEN (mutant)<br />
 
*Myotubularin-related protein (MTMR)
 
**[[1zvr]] – hMTMR2 PH-gram and phosphatase domains (mutant)<br />
**[[1zsq]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate<br />
**[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br />
**[[2yf0]] – hMTMR6<br />


*MAPK phosphatase see [[MAP kinase phosphatase]]
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
Retrieved from "https://proteopedia.org/Dual_specificity_phosphatase"