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==Nuclear Magnetic Resonance Structure of the Human Polyoma JC Virus Agnoprotein==
==Nuclear Magnetic Resonance Structure of the Human Polyoma JC Virus Agnoprotein==
<StructureSection load='5nhq' size='340' side='right' caption='[[5nhq]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''>
<StructureSection load='5nhq' size='340' side='right'caption='[[5nhq]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5nhq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NHQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5nhq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/JC_polyomavirus JC polyomavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NHQ FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nhq OCA], [http://pdbe.org/5nhq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nhq RCSB], [http://www.ebi.ac.uk/pdbsum/5nhq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nhq ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nhq OCA], [https://pdbe.org/5nhq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nhq RCSB], [https://www.ebi.ac.uk/pdbsum/5nhq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nhq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AGNO_POVJC AGNO_POVJC]] Alters the structure of the nuclear envelope by interacting with host CBX5 and disrupting CBX5 association with LBR. Involved in the perinuclear-nuclear localization of the capsid protein VP1 during virion assembly and maturation. Plays an important role in the release of progeny virions from infected cells and in viral propagation, probably by acting as a viral ionic channel in the host plasma membrane. Allows influx of extracellular calcium ions in the host cell. May contribute to viral genome transcription and translation of viral late proteins.<ref>PMID:11517407</ref> <ref>PMID:12165856</ref> <ref>PMID:20300659</ref>
[https://www.uniprot.org/uniprot/AGNO_POVJC AGNO_POVJC] Alters the structure of the nuclear envelope by interacting with host CBX5 and disrupting CBX5 association with LBR. Involved in the perinuclear-nuclear localization of the capsid protein VP1 during virion assembly and maturation. Plays an important role in the release of progeny virions from infected cells and in viral propagation, probably by acting as a viral ionic channel in the host plasma membrane. Allows influx of extracellular calcium ions in the host cell. May contribute to viral genome transcription and translation of viral late proteins.<ref>PMID:11517407</ref> <ref>PMID:12165856</ref> <ref>PMID:20300659</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Abou-Gharbia, M]]
[[Category: JC polyomavirus]]
[[Category: Bouaziz, S]]
[[Category: Large Structures]]
[[Category: Childers, W]]
[[Category: Abou-Gharbia M]]
[[Category: Condra, J]]
[[Category: Bouaziz S]]
[[Category: Coric, P]]
[[Category: Childers W]]
[[Category: Safak, M]]
[[Category: Condra J]]
[[Category: Saribas, A S]]
[[Category: Coric P]]
[[Category: White, M K]]
[[Category: Safak M]]
[[Category: Agnoprotein]]
[[Category: Saribas AS]]
[[Category: Alpha-helix]]
[[Category: White MK]]
[[Category: Bkv]]
[[Category: Dimer]]
[[Category: Dna replication]]
[[Category: Intrinsically unstructured]]
[[Category: Jcv]]
[[Category: Merkel cell]]
[[Category: Oligomer]]
[[Category: Polyomavirus]]
[[Category: Progressive multifocal leukoencephalopathy]]
[[Category: Sv40]]
[[Category: Viral protein]]