1uv0: Difference between revisions

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[[Image:1uv0.jpg|left|200px]]


{{Structure
==Pancreatitis-associated protein 1 from human==
|PDB= 1uv0 |SIZE=350|CAPTION= <scene name='initialview01'>1uv0</scene>, resolution 1.78&Aring;
<StructureSection load='1uv0' size='340' side='right'caption='[[1uv0]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[1uv0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UV0 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uv0 OCA], [https://pdbe.org/1uv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uv0 RCSB], [https://www.ebi.ac.uk/pdbsum/1uv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uv0 ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uv0 OCA], [http://www.ebi.ac.uk/pdbsum/1uv0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uv0 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/REG3A_HUMAN REG3A_HUMAN] Might be a stress protein involved in the control of bacterial proliferation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/1uv0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uv0 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Human HIP/PAP is an adhesion protein expressed in normal pancreatic and Paneth cells and overexpressed in hepatocellular carcinoma. HIP/PAP was crystallized using the Hampton Research Crystal Screen and SAmBA software to define the optimal crystallization protocol. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 30.73, b = 49.35, c = 92.15 A and one molecule in the asymmetric unit. Flash-frozen crystals diffract to 1. 78 A resolution using synchrotron radiation. A molecular-replacement solution was obtained using the human Reg/lithostathine structure and the AMoRe software.


'''PANCREATITIS-ASSOCIATED PROTEIN 1 FROM HUMAN'''
Crystallization and preliminary crystallographic study of HIP/PAP, a human C-lectin overexpressed in primary liver cancers.,Abergel C, Chenivesse S, Stinnakre MG, Guasco S, Brechot C, Claverie JM, Devinoy E, Christa L Acta Crystallogr D Biol Crystallogr. 1999 Aug;55(Pt 8):1487-9. PMID:10417404<ref>PMID:10417404</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
1UV0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UV0 OCA].
<div class="pdbe-citations 1uv0" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Abergel, C.]]
[[Category: Abergel C]]
[[Category: Christal, L.]]
[[Category: Christal L]]
[[Category: Shepard, W.]]
[[Category: Shepard W]]
[[Category: acute phase]]
[[Category: c-type]]
[[Category: inflammatory response]]
[[Category: lectin]]
[[Category: secreted]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:15:42 2008''
Retrieved from "https://proteopedia.org/1uv0"