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==E. coli DNA Gyrase B 24 kDa ATPase domain in complex with 1-ethyl-3-[8-methyl-5-(2-methyl-pyridin-4-yl)-isoquinolin-3-yl]-urea==
==E. coli DNA Gyrase B 24 kDa ATPase domain in complex with 1-ethyl-3-[8-methyl-5-(2-methyl-pyridin-4-yl)-isoquinolin-3-yl]-urea==
<StructureSection load='5mmn' size='340' side='right' caption='[[5mmn]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5mmn' size='340' side='right'caption='[[5mmn]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5mmn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MMN FirstGlance]. <br>
<table><tr><td colspan='2'>[[5mmn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MMN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O54:1-ETHYL-3-[8-METHYL-5-(2-METHYLPYRIDIN-4-YL)ISOQUINOLIN-3-YL]UREA'>O54</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O54:1-ETHYL-3-[8-METHYL-5-(2-METHYLPYRIDIN-4-YL)ISOQUINOLIN-3-YL]UREA'>O54</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mmn OCA], [http://pdbe.org/5mmn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mmn RCSB], [http://www.ebi.ac.uk/pdbsum/5mmn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mmn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mmn OCA], [https://pdbe.org/5mmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mmn RCSB], [https://www.ebi.ac.uk/pdbsum/5mmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mmn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GYRB_ECO57 GYRB_ECO57]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]  
[https://www.uniprot.org/uniprot/GYRB_ECO57 GYRB_ECO57] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5mmn" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5mmn" style="background-color:#fffaf0;"></div>
==See Also==
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Blumstein, A C]]
[[Category: Escherichia coli O157:H7]]
[[Category: Bruyere, T]]
[[Category: Large Structures]]
[[Category: Bur, D]]
[[Category: Blumstein A-C]]
[[Category: Chambovey, A]]
[[Category: Bruyere T]]
[[Category: Ertel, E A]]
[[Category: Bur D]]
[[Category: Gude, M]]
[[Category: Chambovey A]]
[[Category: Hubschwerlen, C]]
[[Category: Ertel EA]]
[[Category: Jacob, L]]
[[Category: Gude M]]
[[Category: Kimmerlin, T]]
[[Category: Hubschwerlen C]]
[[Category: Panchaud, P]]
[[Category: Jacob L]]
[[Category: Pfeifer, T]]
[[Category: Kimmerlin T]]
[[Category: Prade, L]]
[[Category: Panchaud P]]
[[Category: Ritz, D]]
[[Category: Pfeifer T]]
[[Category: Rueedi, G]]
[[Category: Prade L]]
[[Category: Seiler, P]]
[[Category: Ritz D]]
[[Category: Inhibitor]]
[[Category: Rueedi G]]
[[Category: Isomerase]]
[[Category: Seiler P]]
Retrieved from "https://proteopedia.org/5mmn"