5grm: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5grm is ~~ON HOLD until Paper Publication~~

==Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP)==

== Structural highlights ==

<table><tr><td colspan='2'>[[5grm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GRM OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5GRM FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5grm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5grm OCA], [https://pdbe.org/5grm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5grm RCSB], [https://www.ebi.ac.uk/pdbsum/5grm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5grm ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/STING_RAT STING_RAT] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state (PubMed:26669264). May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway (By similarity). Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP; the precise binding affinity may be species-specific and rat TMEM173/STING is preferentially activated by 3'-3' linked cGAMP (PubMed:26669264).[UniProtKB:Q86WV6]<ref>PMID:26669264</ref>

~~Authors: Zhang, H., Han, M.J., Tao, J.L., Ye, Z.Y., Du, X.X., Deng, M.J., Zhang, X.Y., Li, L.F., Jiang, Z.F., Su, X.D.~~

==See Also==

*[[Stimulator of interferon genes protein|Stimulator of interferon genes protein]]

~~Description: Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP)~~

== References ==

[[Category: ~~Unreleased~~ Structures]]

[[Category: ~~Zhang, H~~]]

__TOC__

[[Category: ~~Li, L.F~~]]

</StructureSection>

[[Category: ~~Deng, M.J~~]]

[[Category: Large Structures]]

[[Category: ~~Du, X.X~~]]

[[Category: Rattus norvegicus]]

[[Category: ~~Su, X.D~~]]

[[Category: Deng MJ]]

[[Category: ~~Ye, Z.Y~~]]

[[Category: Du XX]]

[[Category: ~~Jiang, Z.F~~]]

[[Category: Han MJ]]

[[Category: Tao~~, J.L~~]]

[[Category: Jiang ZF]]

[[Category: ~~Han, M.J~~]]

[[Category: Li LF]]

[[Category: Zhang~~, X.Y~~]]

[[Category: Su XD]]

[[Category: Tao JL]]

[[Category: Ye ZY]]

[[Category: Zhang H]]

[[Category: Zhang XY]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5grm is ON HOLD  until Paper Publication
+==Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP)==
+<StructureSection load='5grm' size='340' side='right'caption='[[5grm]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5grm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GRM FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5grm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5grm OCA], [https://pdbe.org/5grm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5grm RCSB], [https://www.ebi.ac.uk/pdbsum/5grm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5grm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/STING_RAT STING_RAT] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state (PubMed:26669264). May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway (By similarity). Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP; the precise binding affinity may be species-specific and rat TMEM173/STING is preferentially activated by 3'-3' linked cGAMP (PubMed:26669264).[UniProtKB:Q86WV6]<ref>PMID:26669264</ref>
-Authors: Zhang, H., Han, M.J., Tao, J.L., Ye, Z.Y., Du, X.X., Deng, M.J., Zhang, X.Y., Li, L.F., Jiang, Z.F., Su, X.D.
+==See Also==
+*[[Stimulator of interferon genes protein|Stimulator of interferon genes protein]]
-Description: Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP)
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Zhang, H]]
+__TOC__
-[[Category: Li, L.F]]
+</StructureSection>
-[[Category: Deng, M.J]]
+[[Category: Large Structures]]
-[[Category: Du, X.X]]
+[[Category: Rattus norvegicus]]
-[[Category: Su, X.D]]
+[[Category: Deng MJ]]
-[[Category: Ye, Z.Y]]
+[[Category: Du XX]]
-[[Category: Jiang, Z.F]]
+[[Category: Han MJ]]
-[[Category: Tao, J.L]]
+[[Category: Jiang ZF]]
-[[Category: Han, M.J]]
+[[Category: Li LF]]
-[[Category: Zhang, X.Y]]
+[[Category: Su XD]]
+[[Category: Tao JL]]
+[[Category: Ye ZY]]
+[[Category: Zhang H]]
+[[Category: Zhang XY]]