5xa4: Difference between revisions

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'''Unreleased structure'''


The entry 5xa4 is ON HOLD  until Paper Publication
==Crystal Structure of HasAp with Fe-5,15-Diazaporphyrin==
<StructureSection load='5xa4' size='340' side='right'caption='[[5xa4]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xa4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XA4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xa4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xa4 OCA], [https://pdbe.org/5xa4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xa4 RCSB], [https://www.ebi.ac.uk/pdbsum/5xa4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xa4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G3XD33_PSEAE G3XD33_PSEAE]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Iron(III)-5,15-diphenylporphyrin and several derivatives were accommodated by HasA, a heme acquisition protein secreted by Pseudomonas aeruginosa, despite possessing bulky substituents at the meso position of the porphyrin. Crystal structure analysis revealed that the two phenyl groups at the meso positions of porphyrin extend outside HasA. It was shown that the growth of P. aeruginosa was inhibited in the presence of HasA coordinating the synthetic porphyrins under iron-limiting conditions, and that the structure of the synthetic porphyrins greatly affects the inhibition efficiency.


Authors: Shoji, O., Uehara, H., Sugimoto, H., Shiro, Y., Watanabe, Y.
Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group.,Uehara H, Shisaka Y, Nishimura T, Sugimoto H, Shiro Y, Miyake Y, Shinokubo H, Watanabe Y, Shoji O Angew Chem Int Ed Engl. 2017 Nov 27;56(48):15279-15283. doi:, 10.1002/anie.201707212. Epub 2017 Oct 9. PMID:28921809<ref>PMID:28921809</ref>


Description: Crystal Structure of HasAp with Fe-5,15-Diazaporphyrin
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Shiro, Y]]
<div class="pdbe-citations 5xa4" style="background-color:#fffaf0;"></div>
[[Category: Uehara, H]]
== References ==
[[Category: Sugimoto, H]]
<references/>
[[Category: Shoji, O]]
__TOC__
[[Category: Watanabe, Y]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Shiro Y]]
[[Category: Shoji O]]
[[Category: Sugimoto H]]
[[Category: Uehara H]]
[[Category: Watanabe Y]]
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