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==Crystal structure of pathogenic mutants of human mitochodnrial PheRS==
==Crystal structure of pathogenic mutants of human mitochodnrial PheRS==
<StructureSection load='5mgh' size='340' side='right' caption='[[5mgh]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
<StructureSection load='5mgh' size='340' side='right'caption='[[5mgh]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5mgh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MGH FirstGlance]. <br>
<table><tr><td colspan='2'>[[5mgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MGH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine--tRNA_ligase Phenylalanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.20 6.1.1.20] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mgh OCA], [http://pdbe.org/5mgh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mgh RCSB], [http://www.ebi.ac.uk/pdbsum/5mgh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mgh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mgh OCA], [https://pdbe.org/5mgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mgh RCSB], [https://www.ebi.ac.uk/pdbsum/5mgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mgh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SYFM_HUMAN SYFM_HUMAN]] Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.<ref>PMID:19549855</ref>
[https://www.uniprot.org/uniprot/SYFM_HUMAN SYFM_HUMAN] Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.<ref>PMID:19549855</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5mgh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5mgh" style="background-color:#fffaf0;"></div>
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Phenylalanine--tRNA ligase]]
[[Category: Homo sapiens]]
[[Category: Chrzanowska-Lightowlers, Z]]
[[Category: Large Structures]]
[[Category: Kartvelishvili, E]]
[[Category: Chrzanowska-Lightowlers Z]]
[[Category: Moor, N]]
[[Category: Kartvelishvili E]]
[[Category: Safro, M]]
[[Category: Moor N]]
[[Category: Tworowski, D]]
[[Category: Safro M]]
[[Category: Vernon, H]]
[[Category: Tworowski D]]
[[Category: Wang, J]]
[[Category: Vernon H]]
[[Category: Wong, L J]]
[[Category: Wang J]]
[[Category: Aminoacylation]]
[[Category: Wong L-J]]
[[Category: Crystal structure of pathogenic human mitochondrial pher]]
[[Category: Kinetik study]]
[[Category: Ligase]]
[[Category: Molecular dynamic]]
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