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==BACE1 in complex with inhibitor 5g==
==BACE1 in complex with inhibitor 5g==
<StructureSection load='5v0n' size='340' side='right' caption='[[5v0n]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='5v0n' size='340' side='right'caption='[[5v0n]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5v0n]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V0N FirstGlance]. <br>
<table><tr><td colspan='2'>[[5v0n]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V0N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8W4:N-{(1S,2S)-1-[(2S)-4-BENZYL-3-OXOPIPERAZIN-2-YL]-1-HYDROXY-3-PHENYLPROPAN-2-YL}-7-ETHYL-1,3,3-TRIMETHYL-2,2-DIOXO-1,2,3,4-TETRAHYDRO-2LAMBDA~6~-[1,2,5]THIADIAZEPINO[3,4,5-HI]INDOLE-9-CARBOXAMIDE'>8W4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.155&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8W4:N-{(1S,2S)-1-[(2S)-4-BENZYL-3-OXOPIPERAZIN-2-YL]-1-HYDROXY-3-PHENYLPROPAN-2-YL}-7-ETHYL-1,3,3-TRIMETHYL-2,2-DIOXO-1,2,3,4-TETRAHYDRO-2LAMBDA~6~-[1,2,5]THIADIAZEPINO[3,4,5-HI]INDOLE-9-CARBOXAMIDE'>8W4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v0n OCA], [http://pdbe.org/5v0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v0n RCSB], [http://www.ebi.ac.uk/pdbsum/5v0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v0n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v0n OCA], [https://pdbe.org/5v0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v0n RCSB], [https://www.ebi.ac.uk/pdbsum/5v0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v0n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5v0n" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5v0n" style="background-color:#fffaf0;"></div>
==See Also==
*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Memapsin 2]]
[[Category: Homo sapiens]]
[[Category: Ghosh, A]]
[[Category: Large Structures]]
[[Category: Mesecar, A]]
[[Category: Ghosh A]]
[[Category: Yen, Y C]]
[[Category: Mesecar A]]
[[Category: Bace1-inhibitor complex]]
[[Category: Yen Y-C]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
Retrieved from "https://proteopedia.org/5v0n"