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New page: '''Unreleased structure''' The entry 5nu8 is ON HOLD until Paper Publication Authors: Perduca, M., Monaco, H.L., Galliano, M. Description: Structure of human urine RBP4 saturated with ...
 
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'''Unreleased structure'''


The entry 5nu8 is ON HOLD  until Paper Publication
==Structure of human urine RBP4 saturated with palmitate==
<StructureSection load='5nu8' size='340' side='right'caption='[[5nu8]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5nu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NU8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nu8 OCA], [https://pdbe.org/5nu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nu8 RCSB], [https://www.ebi.ac.uk/pdbsum/5nu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nu8 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[https://omim.org/entry/180250 180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
== Function ==
[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
RBP4 (plasma retinol-binding protein) is the 21kDa transporter of all-trans retinol that circulates in plasma as a moderately tight 1:1 molar complex of the vitamin with the protein. RBP4 is primarily synthesized in the liver but is also produced by adipose tissue and circulates bound to a larger protein, transthyretin, TTR, that serves to increase its molecular mass and thus avoid its elimination by glomerular filtration. This paper reports the high resolution three-dimensional structures of human RBP4 naturally lacking bound retinol purified from plasma, urine and amniotic fluid. In all these crystals we found a fatty acid molecule bound in the hydrophobic ligand-binding site, a result confirmed by mass spectrometry measurements. In addition we also report the 1.5A resolution structures of human holo-RBP4 and of the protein saturated with palmitic and lauric acid and discuss the interaction of the fatty acids and retinol with the protein.


Authors: Perduca, M., Monaco, H.L., Galliano, M.
Human plasma retinol-binding protein (RBP4) is also a fatty acid-binding protein.,Perduca M, Nicolis S, Mannucci B, Galliano M, Monaco HL Biochim Biophys Acta. 2018 Apr;1863(4):458-466. doi:, 10.1016/j.bbalip.2018.01.010. PMID:29414511<ref>PMID:29414511</ref>


Description: Structure of human urine RBP4 saturated with palmitate
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Perduca, M]]
<div class="pdbe-citations 5nu8" style="background-color:#fffaf0;"></div>
[[Category: Monaco, H.L]]
 
[[Category: Galliano, M]]
==See Also==
*[[Retinol-binding protein 3D structures|Retinol-binding protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Galliano M]]
[[Category: Monaco HL]]
[[Category: Perduca M]]
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