5nz0: Difference between revisions

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New page: '''Unreleased structure''' The entry 5nz0 is ON HOLD Authors: Blaszczyk, M., Mendes, V., Nikiforov, P.O., Blundell, T.L. Description: Structure of Transcriptional Regulatory Repressor ...
 
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'''Unreleased structure'''


The entry 5nz0 is ON HOLD
==Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with linezolid==
<StructureSection load='5nz0' size='340' side='right'caption='[[5nz0]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5nz0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NZ0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.825&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZLD:N-{[(5S)-3-(3-FLUORO-4-MORPHOLIN-4-YLPHENYL)-2-OXO-1,3-OXAZOLIDIN-5-YL]METHYL}ACETAMIDE'>ZLD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nz0 OCA], [https://pdbe.org/5nz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nz0 RCSB], [https://www.ebi.ac.uk/pdbsum/5nz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nz0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>


Authors: Blaszczyk, M., Mendes, V., Nikiforov, P.O., Blundell, T.L.
==See Also==
 
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
Description: Structure of Transcriptional Regulatory Repressor Protein -EthR from Mycobacterium Tuberculosis in complex with linezolid
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Blundell, T.L]]
__TOC__
[[Category: Mendes, V]]
</StructureSection>
[[Category: Blaszczyk, M]]
[[Category: Large Structures]]
[[Category: Nikiforov, P.O]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Blaszczyk M]]
[[Category: Blundell TL]]
[[Category: Mendes V]]
[[Category: Nikiforov PO]]
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