SecA: Difference between revisions
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<StructureSection load='3jv2' size=' | <StructureSection load='3jv2' size='350' side='right' scene='' caption='Dimer of monomeric SecA complex with peptide (pink and yellow), ADP and Mg+2 ion (green), [[3jv2]]' pspeed='8'> | ||
=Introduction= | =Introduction= | ||
The [http://www.nature.com/nature/journal/v455/n7215/full/nature07335.html SecA] ATPase '''SecA''' drives the post-translational translocation of proteins through the SecY channel in the bacterial inner membrane. SecA is a dimer that can dissociate into monomers under certain conditions. Many bacterial proteins are transported post-translationally across the inner membrane by the Sec machinery, which consists of two essential components (1-4). One is the SecY complex, which forms a conserved heterotrimeric protein-conducting channel in the inner membrane.<ref name=journal1>PMID:15618215</ref> The other is SecA, a cytoplasmic ATPase, which "pushes" substrate polypeptide chains through the SecY channel.<ref name=journal1/> . For additional details see [[SecA PBD motions]]. | The [http://www.nature.com/nature/journal/v455/n7215/full/nature07335.html SecA] ATPase '''SecA''' or '''preprotein translocase subunit SecA''' drives the post-translational translocation of proteins through the SecY channel in the bacterial inner membrane. SecA is a dimer that can dissociate into monomers under certain conditions. Many bacterial proteins are transported post-translationally across the inner membrane by the Sec machinery, which consists of two essential components (1-4). One is the SecY complex, which forms a conserved heterotrimeric protein-conducting channel in the inner membrane.<ref name=journal1>PMID:15618215</ref> The other is SecA, a cytoplasmic ATPase, which "pushes" substrate polypeptide chains through the SecY channel.<ref name=journal1/> . For additional details see [[SecA PBD motions]]. | ||
=Structure= | =Structure= | ||
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**[[2ibm]], [[1tf5]], [[1m6n]] - BsSecA<br /> | **[[2ibm]], [[1tf5]], [[1m6n]] - BsSecA<br /> | ||
**[[3bxz]] - EcSecA (mutant) – ''Escherichia coli''<br /> | **[[3bxz]] - EcSecA (mutant) – ''Escherichia coli''<br /> | ||
**[[2fsf]] – EcSecA<br /> | **[[2fsf]] , [[6gox]] – EcSecA<br /> | ||
**[[1tm6]], [[1sx0]], [[1sx1]] – EcSecA zinc-binding domain - NMR<br /> | **[[1tm6]], [[1sx0]], [[1sx1]] – EcSecA zinc-binding domain - NMR<br /> | ||
**[[3jux]], [[4ys0]] – TmSecA – ''Thermotoga maritima''<br /> | **[[3jux]], [[4ys0]] – TmSecA – ''Thermotoga maritima''<br /> | ||
**[[2ipc]] – SecA – ''Thermus thermophilus''<br /> | **[[2ipc]] – SecA – ''Thermus thermophilus''<br /> | ||
**[[1nl3]] – MtSecA – ''Mycobacterium tuberculosis'' | **[[1nl3]] – MtSecA 1 – ''Mycobacterium tuberculosis''<br /> | ||
**[[4uaq]] – MtSecA 2<br /> | |||
**[[6sxh]] – PdSecA 2 – ''Peptoclostridium difficile''<br /> | |||
*SecA complexes | *SecA complexes | ||
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**[[3jv2]] – BsSecA + peptide <br /> | **[[3jv2]] – BsSecA + peptide <br /> | ||
**[[1tf2]], [[1m74]] - BsSecA + ADP <BR /> | **[[1tf2]], [[1m74]] - BsSecA + ADP <BR /> | ||
**[[5eul]] - BsSecA + SecY + SecE + AYC08<br /> | |||
**[[3dl8]] – BsSecA + AaSecY + AaSecE + AaSecG – ''Aquifex aeolicus''<br /> | **[[3dl8]] – BsSecA + AaSecY + AaSecE + AaSecG – ''Aquifex aeolicus''<br /> | ||
**[[6itc]] – BsSecA + SecY + SecE + nanobody + GFP + peptide – Cryo EM<br /> | |||
**[[7xha]], [[7xhb]] – BsSecA + GtSecY + GtSecE + translocating polypeptide + ADP – ''Geoacillus thermodenitrificans'' - Cryo EM<br /> | |||
**[[3din]] - TmSecA + TmSecY + TmSecE + TmSecG<br /> | **[[3din]] - TmSecA + TmSecY + TmSecE + TmSecG<br /> | ||
**[[1ozb]] - SecA + SecB – Haemophilus influenzae<br /> | **[[1ozb]] - SecA + SecB – Haemophilus influenzae<br /> | ||
**[[6s0k]] – EcSecA in ribosome – Cryo EM<br /> | |||
**[[2vda]] – EcSecA + maltoporin signal peptide <br /> | **[[2vda]] – EcSecA + maltoporin signal peptide <br /> | ||
**[[2fsg]] - EcSecA + ATP <BR /> | **[[2fsg]] - EcSecA + ATP <BR /> | ||
**[[2fsi]] - EcSecA + ADP <BR /> | **[[2fsi]] - EcSecA + ADP <BR /> | ||
**[[5k9t]] - EcSecA (mutant) + ADP <BR /> | |||
**[[2fsh]] - EcSecA + AMPPNP <BR /> | **[[2fsh]] - EcSecA + AMPPNP <BR /> | ||
**[[1nkt]] - MtSecA + ADP <BR /> | **[[1nkt]] - MtSecA 1 + ADP <BR /> | ||
**[[4ys0]] - TmSecA + ADP <BR /> | |||
**[[6t4h]] – PdSecA 2 + ATP derivative<br /> | |||
}} | }} | ||
=References= | =References= | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
