2wwe: Difference between revisions
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==Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma== | ==Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma== | ||
<StructureSection load='2wwe' size='340' side='right' caption='[[2wwe]], [[Resolution|resolution]] 1.25Å' scene=''> | <StructureSection load='2wwe' size='340' side='right'caption='[[2wwe]], [[Resolution|resolution]] 1.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wwe]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWE OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[2wwe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WWE FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wwe OCA], [https://pdbe.org/2wwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wwe RCSB], [https://www.ebi.ac.uk/pdbsum/2wwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wwe ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/P3C2G_HUMAN P3C2G_HUMAN] Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (By similarity). May play a role in SDF1A-stimulated chemotaxis (By similarity).[UniProtKB:O70167][UniProtKB:O70173] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2wwe_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2wwe_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 18: | Line 21: | ||
==See Also== | ==See Also== | ||
*[[Phosphoinositide 3- | *[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Berglund | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Berglund H]] | ||
[[Category: Collins | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Collins R]] | ||
[[Category: Flodin | [[Category: Edwards AM]] | ||
[[Category: Flores | [[Category: Flodin S]] | ||
[[Category: Graslund | [[Category: Flores A]] | ||
[[Category: Hammarstrom | [[Category: Graslund S]] | ||
[[Category: Johansson | [[Category: Hammarstrom M]] | ||
[[Category: Johansson | [[Category: Johansson A]] | ||
[[Category: Kallas | [[Category: Johansson I]] | ||
[[Category: Karlberg | [[Category: Kallas A]] | ||
[[Category: Kotyenova | [[Category: Karlberg T]] | ||
[[Category: Kotzch | [[Category: Kotyenova T]] | ||
[[Category: Kraulis | [[Category: Kotzch A]] | ||
[[Category: Markova | [[Category: Kraulis P]] | ||
[[Category: Moche | [[Category: Markova N]] | ||
[[Category: Nielsen | [[Category: Moche M]] | ||
[[Category: Nordlund | [[Category: Nielsen TK]] | ||
[[Category: Nyman | [[Category: Nordlund P]] | ||
[[Category: Persson | [[Category: Nyman T]] | ||
[[Category: Roos | [[Category: Persson C]] | ||
[[Category: Roos AK]] | |||
[[Category: Schuler | [[Category: Schuler H]] | ||
[[Category: Schutz | [[Category: Schutz P]] | ||
[[Category: Siponen | [[Category: Siponen MI]] | ||
[[Category: Svensson | [[Category: Svensson L]] | ||
[[Category: Thorsell | [[Category: Thorsell AG]] | ||
[[Category: Tresaugues | [[Category: Tresaugues L]] | ||
[[Category: Wahlberg | [[Category: Van Der Berg S]] | ||
[[Category: Weigelt | [[Category: Wahlberg E]] | ||
[[Category: Welin | [[Category: Weigelt J]] | ||
[[Category: Wisniewska | [[Category: Welin M]] | ||
[[Category: Wisniewska M]] | |||
