5o1p: Difference between revisions
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==Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase.== | |||
<StructureSection load='5o1p' size='340' side='right'caption='[[5o1p]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5o1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O1P FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o1p OCA], [https://pdbe.org/5o1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o1p RCSB], [https://www.ebi.ac.uk/pdbsum/5o1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o1p ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN] Hyperlysinemia;Saccharopinuria. The disease is caused by mutations affecting the gene represented in this entry. The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS.<ref>PMID:24847004</ref> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN] Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively. | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Pena | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith C]] | ||
[[Category: Strain-Damerell | [[Category: Arruda P]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: | [[Category: Burgess-Brown N]] | ||
[[Category: | [[Category: Collins P]] | ||
[[Category: | [[Category: Edwards A]] | ||
[[Category: Goubin S]] | |||
[[Category: Kopec J]] | |||
[[Category: Krojer T]] | |||
[[Category: Kupinska K]] | |||
[[Category: Pena IA]] | |||
[[Category: Rembeza E]] | |||
[[Category: Strain-Damerell C]] | |||
[[Category: Talon R]] | |||
[[Category: Velupillai S]] | |||
[[Category: Williams E]] | |||
[[Category: Yue WW]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 19:03, 29 November 2023
Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase.
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