Metallothiol transferase FosB: Difference between revisions
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< | <StructureSection load='4nb0' size='350' side='right' caption='Structure of FosB in Staphylococcus aureus complex with cysteine, glycerol and sulfate (PDB code [[4nb0]])' scene=''> | ||
__TOC__ | __TOC__ | ||
==INTRODUCTION== | ==INTRODUCTION== | ||
The '''transcription factor''', DeltaFosB, is known to be involved in some of the physiological mechanisms linked to addiction and compulsive behaviors. Levels of DeltaFosB have been shown to increase in multiple regions of the brain in response to repeated drug exposure as well as stress, certain antipsychotic or antidepressant medications, electroconvulsive seizures, and certain lesions. DeltaFosB is a truncated, highly stable splice variant of the FosB transcription factor whose expression is regulated by alternative splicing of the FosB gene. Due to this splicing, DeltaFosB is known to have a half life five times that of FosB, which is thought to be a basis for addiction <ref name ="James">PMID:25083822</ref>. | The '''transcription factor''', '''DeltaFosB''', is known to be involved in some of the physiological mechanisms linked to addiction and compulsive behaviors. Levels of DeltaFosB have been shown to increase in multiple regions of the brain in response to repeated drug exposure as well as stress, certain antipsychotic or antidepressant medications, electroconvulsive seizures, and certain lesions. DeltaFosB is a truncated, highly stable splice variant of the FosB transcription factor whose expression is regulated by alternative splicing of the FosB gene. Due to this splicing, DeltaFosB is known to have a half life five times that of FosB, which is thought to be a basis for addiction <ref name ="James">PMID:25083822</ref>. | ||
==STRUCTURE== | ==STRUCTURE== | ||
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This effect is underscored by a study which measured levels of DeltaFosB following a period of increased sexual activity <ref>Pitchers, K. K., Vialou, V., Nestler, E. J., Laviolette, S. R., Lehman, M. N., & Coolen, L. M. (2013). Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator. The Journal of Neuroscience,33(8), 3434-3442.x</ref>. After a period of abstinence of 1, 7, or 28 days, levels of DeltaFosB in the Nucleus Accumbens were measured. As found in drug studies, DeltaFosB persisted in the NAc neurons of sexually active rats for at least 28 days after abstaining from the reward behavior. It can be concluded that there are similarities in the effects of both natural and drug rewards on the mesolimbic system. | This effect is underscored by a study which measured levels of DeltaFosB following a period of increased sexual activity <ref>Pitchers, K. K., Vialou, V., Nestler, E. J., Laviolette, S. R., Lehman, M. N., & Coolen, L. M. (2013). Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator. The Journal of Neuroscience,33(8), 3434-3442.x</ref>. After a period of abstinence of 1, 7, or 28 days, levels of DeltaFosB in the Nucleus Accumbens were measured. As found in drug studies, DeltaFosB persisted in the NAc neurons of sexually active rats for at least 28 days after abstaining from the reward behavior. It can be concluded that there are similarities in the effects of both natural and drug rewards on the mesolimbic system. | ||
</StructureSection> | |||
==3D structure of FosB== | ==3D structure of FosB== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[6uci]], [[6ucl]], [[6ucm]] – hFosB Bzip domain 153-219 - human<br /> | |||
[[5vpa]], [[5vpb]], [[5vpc]], [[5vpd]] – hFosB Bzip domain + Jun-D<br /> | |||
[[5vpe]], [[5vpf]] – hFosB Bzip domain + Jun-D + DNA<br /> | |||
[[4ir0]], [[4jd1]], [[5f6q]] – FosB2 – ''Bacillus anthracis''<br /> | [[4ir0]], [[4jd1]], [[5f6q]] – FosB2 – ''Bacillus anthracis''<br /> | ||
[[4nay]], [[4naz]], [[4nb2]] – SaFosB – ''Staphylococcus aureus''<br /> | [[4nay]], [[4naz]], [[4nb2]] – SaFosB – ''Staphylococcus aureus''<br /> | ||
[[4jh1]], [[4jh2]] – BcFosB – ''Bacillus cereu''s<br /> | [[4jh1]], [[4jh2]], [[8g7i]] – BcFosB – ''Bacillus cereu''s<br /> | ||
[[4jh3]], [[4jh4]], [[4jh5]], [[4jh6]] – BcFosB + fosfomycin<br /> | [[4jh3]], [[4jh4]], [[4jh5]], [[4jh6]] – BcFosB + fosfomycin<br /> | ||
[[4jh7]], [[4jh8]], [[4jh9]] – BcFosB + fosfomycin derivative<br /> | [[4jh7]], [[4jh8]], [[4jh9]] – BcFosB + fosfomycin derivative<br /> | ||
[[8dtd]], [[8e7q]], [[8e7r]], [[8g7f]], [[8g7g]], [[8g7h]] – BcFosB + phosphonic acid derivative<br /> | |||
[[4nb0]], [[4nb1]] – SaFosB + cysteine<br /> | [[4nb0]], [[4nb1]] – SaFosB + cysteine<br /> | ||
[[7n7g]] – FosB + fosfomycin – ''Enterococcus faecium''<br /> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
