Virus protease: Difference between revisions

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<StructureSection load='1odw' size='350' side='right' caption='HIV-1 protease dimer complex with tert-butylcarbonate [[1odw]]' scene=' /'>
<StructureSection load='' size='350' side='right' caption='Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry [[1cqq]])' scene='55/554890/Cv/1'>
'''Virus proteases''' include HIV protease, XMRV protease, retropepsin.
__TOC__
HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus.  Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa.  
== Function ==
   
'''Virus protease''' or '''3C protease''' or '''virus proteinase''' are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.<ref>PMID:17305557</ref>  F
 
== Disease ==
 
Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.  Coxsakievirus causes the human diseases myocarditis and pericarditis.
 
== Structural highlights ==
 
Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The <scene name='55/554890/Cv/6'>active site triad contains Cys147, His40 and Glu71</scene> (PDB entry [[1cqq]]).<ref>PMID:10500114</ref> <scene name='55/554890/Cv/5'>Whole binding site</scene>.
 
See also<br />
See also<br />


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*[[Molecular Playground/Dengue Virus Protease]]<br />
*[[Molecular Playground/Dengue Virus Protease]]<br />
*[[Viability of a drug-resistant HIV-1 protease mutant]]<br />
*[[Viability of a drug-resistant HIV-1 protease mutant]]<br />
*[[Molecular Playground/Dengue Virus Protease]]
*[[FMDV 3C]] for Foot-and-Mouth virus protease<br />
 
*[[SARS Coronavirus Main Proteinase]]<br />
*[[SARS-CoV-2 Coronavirus Main Protease]]<br />
*[[Taylor SARS-CoV2 Protease]]<br />
== 3D Structures of Virus protease ==
[[Virus protease 3D structures]]
</StructureSection>
</StructureSection>
== 3D Structures of Virus proteases ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*'''HIV-1 protease''' . See [[Immunodeficiency virus protease]]
*'''HIV-2 protease''' See [[Immunodeficiency virus protease]]
*'''Feline Immunodeficiency virus protease''' See [[Immunodeficiency virus protease]]
*'''Simian Immunodeficiency virus protease''' See [[Immunodeficiency virus protease]]
*'''Xenotropic murine leukemia virus protease'''
**[[3nr6]] – XMRV-PR P14<br />
**[[3p1g]] – XMRV-PR RNase H domain (mutant)
*'''Rous sarcoma virus protease'''
**[[1bai]] – RSVP + polypeptide inhibitor _ Rous sarcoma virus
*'''Human Cytomegalovirus protease'''
**[[1cmv]], [[1lay]] – CMVP (mutant) – human herpes virus 5<br />
**[[1wpo]] – CMVP<br />
**[[2wpo]] - CMVP (mutant) + inhibitor
*'''Varicella-Zoster virus protease'''
**[[1vzv]] - VZVP (mutant) – human herpes virus
*'''Equine infectious anemia virus protease'''
**[[2fmb]] – EIAVP (mutant) + inhibitor
*'''Hepatitis A virus protease'''
**[[2h9h]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
*'''Hepatitis C virus protease'''
**[[2o8m]] – HCVP (mutant)<br />
*'''Orf 17'''
**[[3njq]] – hOrf 17 - human herpes virus 8
*'''Dengue virus protease'''
**[[3u1i]] – DvNs2b + peptide – Dengue virus<br />
**[[3u1j]] – DvNs2b + BPTI<br />
**[[2fom]] - DvNs2b + DvNs3<br />
**[[2whx]] – DvNs3 residues 1475-2092
*'''Herpes simplex virus protease'''
**[[1at3]] – HSV II – human herpesvirus 2
*'''Foot-and-Mouth Disease virus protease'''
**[[2bhg]] – FMDV  – Foot-and-mouth disease virus
*'''Infectious Bronchitis virus protease'''
**[[2q6d]] – IBV – infectious bronchitis virus <br />
**[[2q6f]] – IBV + inhibitor
*'''Yellowtail ascites virus protease'''
**[[4izj]], [[4izk]] – YAV Vp4 (mutant) – yellowtail ascites virus
*'''Pseudorabies virus protease'''
**[[4cx8]] – YAV – pseudorabies virus<br />


}}
==References==
<references />
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 09:59, 18 February 2021

Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry 1cqq)

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References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

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