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==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain.==
==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain.==
<StructureSection load='5x8w' size='340' side='right' caption='[[5x8w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5x8w' size='340' side='right'caption='[[5x8w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5x8w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X8W FirstGlance]. <br>
<table><tr><td colspan='2'>[[5x8w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X8W FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5x8u|5x8u]], [[5x8s|5x8s]], [[5x8x|5x8x]], [[5x8q|5x8q]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8w OCA], [https://pdbe.org/5x8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x8w RCSB], [https://www.ebi.ac.uk/pdbsum/5x8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8w ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8w OCA], [http://pdbe.org/5x8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x8w RCSB], [http://www.ebi.ac.uk/pdbsum/5x8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8w ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.<ref>PMID:9427757</ref> <ref>PMID:7481822</ref> <ref>PMID:9223431</ref> <ref>PMID:9296499</ref> <ref>PMID:9223281</ref> <ref>PMID:10449719</ref> <ref>PMID:12954634</ref> 
[https://www.uniprot.org/uniprot/G1RH57_NOMLE G1RH57_NOMLE]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5x8w" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5x8w" style="background-color:#fffaf0;"></div>
==See Also==
*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Histone acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Adachi, T]]
[[Category: Large Structures]]
[[Category: Doi, S]]
[[Category: Adachi T]]
[[Category: Murase, K]]
[[Category: Doi S]]
[[Category: Noguchi, M]]
[[Category: Murase K]]
[[Category: Nomura, A]]
[[Category: Noguchi M]]
[[Category: Yamaguchi, K]]
[[Category: Nomura A]]
[[Category: Binary complex]]
[[Category: Yamaguchi K]]
[[Category: Inhibitor]]
[[Category: Nuclear receptor]]
[[Category: Transcription-inhibitor complex]]
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