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==TTK kinase domain in complex with BAY 1217389==
==TTK kinase domain in complex with BAY 1217389==
<StructureSection load='5nad' size='340' side='right' caption='[[5nad]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='5nad' size='340' side='right'caption='[[5nad]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5nad]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NAD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NAD FirstGlance]. <br>
<table><tr><td colspan='2'>[[5nad]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NAD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8RH:BAY+1217389'>8RH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8RH:4-[6-[2,3-bis(fluoranyl)-4-methoxy-phenoxy]-8-[3,3,3-tris(fluoranyl)propylamino]imidazo[1,2-b]pyridazin-3-yl]-~{N}-cyclopropyl-2-methyl-benzamide'>8RH</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5n7v|5n7v]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nad OCA], [https://pdbe.org/5nad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nad RCSB], [https://www.ebi.ac.uk/pdbsum/5nad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nad ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nad OCA], [http://pdbe.org/5nad PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nad RCSB], [http://www.ebi.ac.uk/pdbsum/5nad PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nad ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5nad" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5nad" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dual-specificity kinase]]
[[Category: Homo sapiens]]
[[Category: Buijsman, R C]]
[[Category: Large Structures]]
[[Category: Man, J de]]
[[Category: Buijsman RC]]
[[Category: Sterrenburg, J G]]
[[Category: Sterrenburg JG]]
[[Category: Uitdehaag, J C.M]]
[[Category: Uitdehaag JCM]]
[[Category: Willemsen-Seegers, N]]
[[Category: Willemsen-Seegers N]]
[[Category: Zaman, G J.R]]
[[Category: Zaman GJR]]
[[Category: Inhibitor]]
[[Category: De Man J]]
[[Category: Kinase]]
[[Category: Mitosis]]
[[Category: Mps1]]
[[Category: Transferase]]
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