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==2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114==
==2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114==
<StructureSection load='5v56' size='340' side='right' caption='[[5v56]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='5v56' size='340' side='right'caption='[[5v56]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5v56]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V56 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5v56]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_vulgaris_str._Hildenborough Desulfovibrio vulgaris str. Hildenborough] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V56 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=836:N-METHYL-N-[1-[4-(2-METHYLPYRAZOL-3-YL)PHTHALAZIN-1-YL]PIPERIDIN-4-YL]-4-NITRO-2-(TRIFLUOROMETHYL)BENZAMIDE'>836</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5v57|5v57]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=836:N-METHYL-N-[1-[4-(2-METHYLPYRAZOL-3-YL)PHTHALAZIN-1-YL]PIPERIDIN-4-YL]-4-NITRO-2-(TRIFLUOROMETHYL)BENZAMIDE'>836</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v56 OCA], [http://pdbe.org/5v56 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v56 RCSB], [http://www.ebi.ac.uk/pdbsum/5v56 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v56 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v56 OCA], [https://pdbe.org/5v56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v56 RCSB], [https://www.ebi.ac.uk/pdbsum/5v56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v56 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN]] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref>
[https://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref> [https://www.uniprot.org/uniprot/FLAV_DESVH FLAV_DESVH] Low-potential electron donor to a number of redox enzymes.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cherezov, V]]
[[Category: Desulfovibrio vulgaris str. Hildenborough]]
[[Category: Dharmarajan, V]]
[[Category: Homo sapiens]]
[[Category: Ding, K]]
[[Category: Large Structures]]
[[Category: Gati, C]]
[[Category: Cherezov V]]
[[Category: Griffin, P R]]
[[Category: Dharmarajan V]]
[[Category: Han, G W]]
[[Category: Ding K]]
[[Category: Hanson, M A]]
[[Category: Gati C]]
[[Category: Hunter, M S]]
[[Category: Griffin PR]]
[[Category: Ishchenko, A]]
[[Category: Han GW]]
[[Category: Lin, X]]
[[Category: Hanson MA]]
[[Category: Nelson, G]]
[[Category: Hunter MS]]
[[Category: Stevens, R C]]
[[Category: Ishchenko A]]
[[Category: Tan, W]]
[[Category: Lin X]]
[[Category: Tao, H]]
[[Category: Nelson G]]
[[Category: Wu, Y]]
[[Category: Stevens RC]]
[[Category: Xu, F]]
[[Category: Tan W]]
[[Category: Yang, J]]
[[Category: Tao H]]
[[Category: Ye, L]]
[[Category: Wu Y]]
[[Category: Zhang, X]]
[[Category: Xu F]]
[[Category: Zhao, F]]
[[Category: Yang J]]
[[Category: Zhao, S]]
[[Category: Ye L]]
[[Category: 7tm domain]]
[[Category: Zhang X]]
[[Category: Class f]]
[[Category: Zhao F]]
[[Category: Extracellular cystein-rich domain]]
[[Category: Zhao S]]
[[Category: Flavodoxin]]
[[Category: Gpcr]]
[[Category: Gpcr hedgehog signaling]]
[[Category: Hinge domain]]
[[Category: Human smoothened receptor complex]]
[[Category: Lcp]]
[[Category: Membrane protein]]
[[Category: Tc114]]
[[Category: Xfel]]
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