2vkv: Difference between revisions

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==TetR (BD) variant L17G with reverse phenotype==
==TetR (BD) variant L17G with reverse phenotype==
<StructureSection load='2vkv' size='340' side='right' caption='[[2vkv]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
<StructureSection load='2vkv' size='340' side='right'caption='[[2vkv]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vkv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VKV FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vkv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VKV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TDC:5A,6-ANHYDROTETRACYCLINE'>TDC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a6i|1a6i]], [[2vke|2vke]], [[1qpi|1qpi]], [[1bjz|1bjz]], [[1du7|1du7]], [[2trt|2trt]], [[1ork|1ork]], [[1bj0|1bj0]], [[2tct|2tct]], [[1bjy|1bjy]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TDC:5A,6-ANHYDROTETRACYCLINE'>TDC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkv OCA], [http://pdbe.org/2vkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vkv RCSB], [http://www.ebi.ac.uk/pdbsum/2vkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkv OCA], [https://pdbe.org/2vkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vkv RCSB], [https://www.ebi.ac.uk/pdbsum/2vkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TETR2_ECOLX TETR2_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.  
[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vkv_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vkv_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Tetracycline repressor protein|Tetracycline repressor protein]]
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Egerer-Sieber, C]]
[[Category: Escherichia coli]]
[[Category: Henssler, E M]]
[[Category: Large Structures]]
[[Category: Hillen, W]]
[[Category: Egerer-Sieber C]]
[[Category: Muller, Y A]]
[[Category: Henssler EM]]
[[Category: Resch, M]]
[[Category: Hillen W]]
[[Category: Schiltz, E]]
[[Category: Muller YA]]
[[Category: Sevvana, M]]
[[Category: Resch M]]
[[Category: Striegl, H]]
[[Category: Schiltz E]]
[[Category: Anhydrotetracycline]]
[[Category: Sevvana M]]
[[Category: Antibiotic resistance]]
[[Category: Striegl H]]
[[Category: Bacterial repressor]]
[[Category: Disorder to order mechanism]]
[[Category: Dna-binding]]
[[Category: Helix-turn-helix motif]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Plasmid]]
[[Category: Repressor]]
[[Category: Reverse phenotype]]
[[Category: Tetr]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
Retrieved from "https://proteopedia.org/2vkv"