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==Crystal structure of murine neuroglobin at 310 MPa pressure==
==Crystal structure of murine neuroglobin at 310 MPa pressure==
<StructureSection load='5eqm' size='340' side='right' caption='[[5eqm]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='5eqm' size='340' side='right'caption='[[5eqm]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5eqm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EQM FirstGlance]. <br>
<table><tr><td colspan='2'>[[5eqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EQM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eet|5eet]], [[5eoh|5eoh]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqm OCA], [http://pdbe.org/5eqm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eqm RCSB], [http://www.ebi.ac.uk/pdbsum/5eqm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eqm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqm OCA], [https://pdbe.org/5eqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eqm RCSB], [https://www.ebi.ac.uk/pdbsum/5eqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eqm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE]] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref>
[https://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5eqm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5eqm" style="background-color:#fffaf0;"></div>
==See Also==
*[[Neuroglobin|Neuroglobin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Girard, E]]
[[Category: Large Structures]]
[[Category: Prange, T]]
[[Category: Mus musculus]]
[[Category: Vallone, B]]
[[Category: Colloc'h N]]
[[Category: H, N Colloc]]
[[Category: Girard E]]
[[Category: Globin]]
[[Category: Prange T]]
[[Category: Oxygen storage-transporter]]
[[Category: Vallone B]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/5eqm"