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==CRYSTALLOGRAPHIC BINDING STUDIES WITH AN ENGINEERED MONOMERIC VARIANT OF TRIOSEPHOSPHATE ISOMERASE==
==CRYSTALLOGRAPHIC BINDING STUDIES WITH AN ENGINEERED MONOMERIC VARIANT OF TRIOSEPHOSPHATE ISOMERASE==
<StructureSection load='2x2g' size='340' side='right' caption='[[2x2g]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2x2g' size='340' side='right'caption='[[2x2g]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2x2g]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2x0m 2x0m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2G FirstGlance]. <br>
<table><tr><td colspan='2'>[[2x2g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2x0m 2x0m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X2G FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v2c|2v2c]], [[1kv5|1kv5]], [[1iih|1iih]], [[6tim|6tim]], [[2wsr|2wsr]], [[3tim|3tim]], [[2x16|2x16]], [[1iig|1iig]], [[2v2h|2v2h]], [[1dkw|1dkw]], [[2vem|2vem]], [[1ttj|1ttj]], [[2x1s|2x1s]], [[2v5l|2v5l]], [[4tim|4tim]], [[2vei|2vei]], [[2x1t|2x1t]], [[5tim|5tim]], [[2x1r|2x1r]], [[1tsi|1tsi]], [[1mss|1mss]], [[2wsq|2wsq]], [[2j27|2j27]], [[1tpf|1tpf]], [[1tpe|1tpe]], [[1tpd|1tpd]], [[2vel|2vel]], [[2vek|2vek]], [[2v0t|2v0t]], [[1trd|1trd]], [[1tri|1tri]], [[1ml1|1ml1]], [[2j24|2j24]], [[2x1u|2x1u]], [[1ag1|1ag1]], [[2ven|2ven]], [[1mtm|1mtm]], [[2v2d|2v2d]], [[1tti|1tti]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2g OCA], [https://pdbe.org/2x2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x2g RCSB], [https://www.ebi.ac.uk/pdbsum/2x2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x2g ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2g OCA], [http://pdbe.org/2x2g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x2g RCSB], [http://www.ebi.ac.uk/pdbsum/2x2g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x2g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TPIS_TRYBB TPIS_TRYBB]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/2x2g_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/2x2g_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Triose Phosphate Isomerase|Triose Phosphate Isomerase]]
*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Triose-phosphate isomerase]]
[[Category: Large Structures]]
[[Category: Casteleijn, M G]]
[[Category: Trypanosoma brucei brucei]]
[[Category: Kapetaniou, E G]]
[[Category: Casteleijn MG]]
[[Category: Lajunen, M]]
[[Category: Kapetaniou EG]]
[[Category: Neubauer, P]]
[[Category: Lajunen M]]
[[Category: Salin, M]]
[[Category: Neubauer P]]
[[Category: Salmon, L]]
[[Category: Salin M]]
[[Category: Vaismaa, M]]
[[Category: Salmon L]]
[[Category: Wierenga, R]]
[[Category: Vaismaa M]]
[[Category: Fatty acid biosynthesis]]
[[Category: Wierenga R]]
[[Category: Gluconeogenesis]]
[[Category: Glycolysis]]
[[Category: Glycosome]]
[[Category: Isomerase]]
[[Category: Lipid synthesis]]
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