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==Second Bromodomain (BD2) from Candida albicans Bdf1 bound to an imidazopyridine (compound 2)==
==Second Bromodomain (BD2) from Candida albicans Bdf1 bound to an imidazopyridine (compound 2)==
<StructureSection load='5n18' size='340' side='right' caption='[[5n18]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
<StructureSection load='5n18' size='340' side='right'caption='[[5n18]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5n18]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N18 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5n18]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N18 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8HZ:4-[8-methyl-3-[(4-methylphenyl)amino]imidazo[1,2-a]pyridin-2-yl]phenol'>8HZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n18 OCA], [http://pdbe.org/5n18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n18 RCSB], [http://www.ebi.ac.uk/pdbsum/5n18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n18 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8HZ:4-[8-methyl-3-[(4-methylphenyl)amino]imidazo[1,2-a]pyridin-2-yl]phenol'>8HZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n18 OCA], [https://pdbe.org/5n18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n18 RCSB], [https://www.ebi.ac.uk/pdbsum/5n18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n18 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BDF1_CANAL BDF1_CANAL]] Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity).  
[https://www.uniprot.org/uniprot/BDF1_CANAL BDF1_CANAL] Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Champleboux, M]]
[[Category: Candida albicans SC5314]]
[[Category: Chauvel, M]]
[[Category: Large Structures]]
[[Category: Cornet, M]]
[[Category: Champleboux M]]
[[Category: Courcon, M]]
[[Category: Chauvel M]]
[[Category: Enfert, C d]]
[[Category: Cornet M]]
[[Category: Ferri, E]]
[[Category: Courcon M]]
[[Category: Garnaud, C]]
[[Category: Ferri E]]
[[Category: Govin, J]]
[[Category: Garnaud C]]
[[Category: Harbut, M]]
[[Category: Govin J]]
[[Category: Hull, M]]
[[Category: Harbut M]]
[[Category: Kashemirov, B A]]
[[Category: Hull M]]
[[Category: Maubon, D]]
[[Category: Kashemirov BA]]
[[Category: McKenna, C E]]
[[Category: Maubon D]]
[[Category: Mietton, F]]
[[Category: McKenna CE]]
[[Category: Petosa, C]]
[[Category: Mietton F]]
[[Category: Spittler, D]]
[[Category: Petosa C]]
[[Category: Zala, N]]
[[Category: Spittler D]]
[[Category: Zhou, Y]]
[[Category: Zala N]]
[[Category: Bromodomain]]
[[Category: Zhou Y]]
[[Category: Transcription]]
[[Category: D'Enfert C]]
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