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==Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site==
==Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site==
<StructureSection load='5x07' size='340' side='right' caption='[[5x07]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='5x07' size='340' side='right'caption='[[5x07]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5x07]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X07 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X07 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5x07]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X07 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x07 OCA], [http://pdbe.org/5x07 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x07 RCSB], [http://www.ebi.ac.uk/pdbsum/5x07 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x07 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.796&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x07 OCA], [https://pdbe.org/5x07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x07 RCSB], [https://www.ebi.ac.uk/pdbsum/5x07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x07 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FOXA2_HUMAN FOXA2_HUMAN]] Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.  
[https://www.uniprot.org/uniprot/FOXA2_HUMAN FOXA2_HUMAN] Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5x07" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5x07" style="background-color:#fffaf0;"></div>
==See Also==
*[[FOX 3D structures|FOX 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chen, L]]
[[Category: Homo sapiens]]
[[Category: Chen, X]]
[[Category: Large Structures]]
[[Category: Chen, Y]]
[[Category: Chen L]]
[[Category: Chen, Z]]
[[Category: Chen X]]
[[Category: Guo, M]]
[[Category: Chen Y]]
[[Category: Jiang, L]]
[[Category: Chen Z]]
[[Category: Li, J]]
[[Category: Guo M]]
[[Category: Qu, L]]
[[Category: Jiang L]]
[[Category: Wu, D]]
[[Category: Li J]]
[[Category: Zhou, Z]]
[[Category: Qu L]]
[[Category: Consensus binding site]]
[[Category: Wu D]]
[[Category: Dna binding protein-dna complex]]
[[Category: Zhou Z]]
[[Category: Forkhead domain]]
[[Category: Foxa2]]
[[Category: Isothermal titration calorimetry]]
[[Category: Itc]]
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