1b34: Difference between revisions

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==CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN==
==CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN==
<StructureSection load='1b34' size='340' side='right' caption='[[1b34]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1b34' size='340' side='right'caption='[[1b34]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1b34]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B34 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1b34]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B34 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b34 OCA], [http://pdbe.org/1b34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b34 RCSB], [http://www.ebi.ac.uk/pdbsum/1b34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1b34 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b34 OCA], [https://pdbe.org/1b34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b34 RCSB], [https://www.ebi.ac.uk/pdbsum/1b34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b34 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SMD1_HUMAN SMD1_HUMAN]] May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA. [[http://www.uniprot.org/uniprot/SMD2_HUMAN SMD2_HUMAN]] Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity).  
[https://www.uniprot.org/uniprot/SMD1_HUMAN SMD1_HUMAN] May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/1b34_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/1b34_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Nucleoprotein|Nucleoprotein]]
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Avis, J M]]
[[Category: Large Structures]]
[[Category: Fortelle, E De La]]
[[Category: Avis JM]]
[[Category: Kambach, C]]
[[Category: De La Fortelle E]]
[[Category: Li, J]]
[[Category: Kambach C]]
[[Category: Nagai, K]]
[[Category: Li J]]
[[Category: Walke, S]]
[[Category: Nagai K]]
[[Category: Young, R J]]
[[Category: Walke S]]
[[Category: Core snrnp domain]]
[[Category: Young RJ]]
[[Category: Rna binding protein]]
[[Category: Sle]]
[[Category: Sm]]
[[Category: Snrnp]]
[[Category: Spliceosome]]
[[Category: Splicing]]
[[Category: Systemic lupus erythematosus]]

Latest revision as of 23:19, 27 December 2023

CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN

1b34, resolution 2.50Å

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