5e9v: Difference between revisions
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==Crystal structure of BRD9 bromodomain in complex with an indolizine ligand== | ==Crystal structure of BRD9 bromodomain in complex with an indolizine ligand== | ||
<StructureSection load='5e9v' size='340' side='right' caption='[[5e9v]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='5e9v' size='340' side='right'caption='[[5e9v]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5e9v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E9V OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5e9v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E9V FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5L0:1-[1-(IMIDAZO[1,2-A]PYRIDIN-5-YL)-7-(MORPHOLIN-4-YL)INDOLIZIN-3-YL]ETHANONE'>5L0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5L0:1-[1-(IMIDAZO[1,2-A]PYRIDIN-5-YL)-7-(MORPHOLIN-4-YL)INDOLIZIN-3-YL]ETHANONE'>5L0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e9v OCA], [https://pdbe.org/5e9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e9v RCSB], [https://www.ebi.ac.uk/pdbsum/5e9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e9v ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN] May play a role in chromatin remodeling and regulation of transcription. | ||
==See Also== | ==See Also== | ||
*[[Bromodomain-containing protein|Bromodomain-containing protein]] | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Brennan PE]] | ||
[[Category: Fedorov | [[Category: Edwards AM]] | ||
[[Category: Hay | [[Category: Fedorov O]] | ||
[[Category: Knapp | [[Category: Hay DA]] | ||
[[Category: Krojer | [[Category: Knapp S]] | ||
[[Category: Nunez-Alonso | [[Category: Krojer T]] | ||
[[Category: Picaud | [[Category: Nunez-Alonso G]] | ||
[[Category: Schofield | [[Category: Picaud S]] | ||
[[Category: Tallant | [[Category: Schofield CJ]] | ||
[[Category: | [[Category: Tallant C]] | ||
[[Category: Von Delft F]] | |||
Latest revision as of 06:18, 5 July 2023
Crystal structure of BRD9 bromodomain in complex with an indolizine ligand
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