P63: Difference between revisions
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<StructureSection load='' size=' | <StructureSection load='' size='350' side='right' caption='P63 DNA-binding domain complex with DNA and Zn+2 atoms (grey) (PDB code [[3us0]])' scene='70/706258/Cv/1'> | ||
== Function == | == Function == | ||
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== Relevance == | == Relevance == | ||
One isoform of p63 is involved in skin development and stem/progenitor cell regulation<ref>PMID:17224652</ref>. | One isoform of p63 is involved in skin development and stem/progenitor cell regulation<ref>PMID:17224652</ref>. Another isoform functions in apoptosis<ref>PMID:16998800</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
*<scene name='70/706258/Cv/ | *<scene name='70/706258/Cv/8'>A-B dimer interactions with DNA</scene>. Water molecules are shown as red spheres. | ||
*<scene name='70/706258/Cv/5'>C-D dimer interactions with DNA</scene>. | *<scene name='70/706258/Cv/5'>C-D dimer interactions with DNA</scene>. | ||
*<scene name='70/706258/Cv/ | *<scene name='70/706258/Cv/7'>Zn coordination site</scene>. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of P63 == | == 3D Structures of P63 == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*p63 DBD | *p63 DBD (153-384) | ||
**[[2rmn]] – hP63 - human - NMR<br /> | **[[2rmn]] – hP63 - human - NMR<br /> | ||
**[[3qym]], [[3qyn]], [[3us0]], [[3us1]], [[3us2]] – hP63 + DNA<br /> | **[[3qym]], [[3qyn]], [[3us0]], [[3us1]], [[3us2]] – hP63 + DNA<br /> | ||
**[[7z71]], [[7z7e]] – hP63 + darpin<br /> | |||
*p63 tetramerization domain | *p63 tetramerization domain (397-455) | ||
**[[3zy0]], [[3zy1]], [[4a9z]] – hP63 <br /> | **[[3zy0]], [[3zy1]], [[4a9z]] – hP63 <br /> | ||
**[[2nb1]] – hP63 + p73 tetramerization domain - NMR<br /> | |||
**[[8p9c]], [[8p9d]], [[8p9e]] – hP63 + p73 tetramerization domain + darpin<br /> | |||
**[[7z73]] – hP63 + darpin<br /> | |||
*p63 C terminal domain | *p63 C terminal domain (501-575) | ||
**[[1rg6]] – hP63 - NMR<br /> | **[[1rg6]] – hP63 - NMR<br /> | ||
*p63 SAM domain | *p63 SAM domain (543-622) | ||
**[[2y9t]] – hP63 - NMR<br /> | **[[2y9t]] – hP63 - NMR<br /> | ||
**[[2y9u]] – hP63 (mutant)<br /> | **[[2y9u]] – hP63 (mutant)<br /> | ||
**[[7z72]] – hP63 + darpin<br /> | |||
**[[5n2o]] – P63 (mutant) - mouse<br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
