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New page: ==Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis is Controlled by a Redox-Sensitive Thiol Switch== <StructureSection load='5onc' size='340' side='right' caption='[...
 
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==Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis is Controlled by a Redox-Sensitive Thiol Switch==
==Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis is Controlled by a Redox-Sensitive Thiol Switch==
<StructureSection load='5onc' size='340' side='right' caption='[[5onc]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='5onc' size='340' side='right'caption='[[5onc]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5onc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ONC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ONC FirstGlance]. <br>
<table><tr><td colspan='2'>[[5onc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ONC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ONC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ubt|4ubt]], [[4ubv|4ubv]], [[4ubw|4ubw]], [[4ubu|4ubu]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_C-acyltransferase Acetyl-CoA C-acyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.16 2.3.1.16] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5onc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5onc OCA], [https://pdbe.org/5onc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5onc RCSB], [https://www.ebi.ac.uk/pdbsum/5onc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5onc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5onc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5onc OCA], [http://pdbe.org/5onc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5onc RCSB], [http://www.ebi.ac.uk/pdbsum/5onc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5onc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FADA5_MYCTU FADA5_MYCTU]] Involved in the beta-oxidation of the cholesterol side chain (PubMed:19822655). It is important for utilization of cholesterol as a sole carbon source in vitro and for full virulence in the chronic stage of mouse lung infection (PubMed:19822655). Catalyzes the thiolysis of 3,22-dioxochol-4-en-24-oyl-CoA to yield 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) and acetyl-CoA (PubMed:25482540). Also able to use acetoacetyl-CoA (AcAcCoA) as substrate (PubMed:19822655).<ref>PMID:19822655</ref> <ref>PMID:25482540</ref>
[https://www.uniprot.org/uniprot/FADA5_MYCTU FADA5_MYCTU] Involved in the beta-oxidation of the cholesterol side chain (PubMed:19822655). It is important for utilization of cholesterol as a sole carbon source in vitro and for full virulence in the chronic stage of mouse lung infection (PubMed:19822655). Catalyzes the thiolysis of 3,22-dioxochol-4-en-24-oyl-CoA to yield 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) and acetyl-CoA (PubMed:25482540). Also able to use acetoacetyl-CoA (AcAcCoA) as substrate (PubMed:19822655).<ref>PMID:19822655</ref> <ref>PMID:25482540</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5onc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5onc" style="background-color:#fffaf0;"></div>
==See Also==
*[[Thiolase 3D structures|Thiolase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Acetyl-CoA C-acyltransferase]]
[[Category: Large Structures]]
[[Category: Kisker, C]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Kuper, J]]
[[Category: Kisker C]]
[[Category: Sampson, N S]]
[[Category: Kuper J]]
[[Category: Schaefer, C]]
[[Category: Sampson NS]]
[[Category: Biosynthetic protein]]
[[Category: Schaefer C]]
[[Category: Cholesterol metabolism]]
[[Category: Lipid degradation]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Oxidative stress]]
[[Category: Steroid metabolism]]
Retrieved from "https://proteopedia.org/5onc"