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==Structure of the A domain of carboxylic acid reductase (CAR) from Nocardia iowensis in complex with AMP==
==Structure of the A domain of carboxylic acid reductase (CAR) from Nocardia iowensis in complex with AMP==
<StructureSection load='5msc' size='340' side='right' caption='[[5msc]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='5msc' size='340' side='right'caption='[[5msc]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5msc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MSC FirstGlance]. <br>
<table><tr><td colspan='2'>[[5msc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nocardia_iowensis Nocardia iowensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MSC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5msc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5msc OCA], [http://pdbe.org/5msc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5msc RCSB], [http://www.ebi.ac.uk/pdbsum/5msc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5msc ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5msc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5msc OCA], [https://pdbe.org/5msc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5msc RCSB], [https://www.ebi.ac.uk/pdbsum/5msc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5msc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CAR_NOCIO CAR_NOCIO]] Catalyzes the reduction of a very wide range of aliphatic carboxylic acids as well as many aryl carboxylic acids into their corresponding aldehydes, by using ATP for energy to drive the reaction. Aryl carboxylic acid substrates include substituted benzoic acids, phenyl-substituted aliphatic acids, heterocyclic carboxylic acids, and polyaromatic ring carboxylic acids. Cannot reduce benzaldehyde to benzyl alcohol.<ref>PMID:15006821</ref> <ref>PMID:17102130</ref> <ref>PMID:9171390</ref> <ref>PMID:9171390</ref>
[https://www.uniprot.org/uniprot/CAR_NOCIO CAR_NOCIO] Catalyzes the reduction of a very wide range of aliphatic carboxylic acids as well as many aryl carboxylic acids into their corresponding aldehydes, by using ATP for energy to drive the reaction. Aryl carboxylic acid substrates include substituted benzoic acids, phenyl-substituted aliphatic acids, heterocyclic carboxylic acids, and polyaromatic ring carboxylic acids. Cannot reduce benzaldehyde to benzyl alcohol.<ref>PMID:15006821</ref> <ref>PMID:17102130</ref> <ref>PMID:9171390</ref> <ref>PMID:9171390</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dunstan, M S]]
[[Category: Large Structures]]
[[Category: Leys, D]]
[[Category: Nocardia iowensis]]
[[Category: Adenylation domain]]
[[Category: Dunstan MS]]
[[Category: Carboxylic acid reductase]]
[[Category: Leys D]]
[[Category: Oxidoreductase]]