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| <StructureSection load='1qq2' size='350' side='right' scene='43/433646/Cv/2' caption='Typical 2-cys peroxiredoxin dimer complex with Cl- ions [[1qq2]]'> | | <StructureSection load='1qq2' size='350' side='right' scene='43/433646/Cv/2' caption='Typical 2-cys peroxiredoxin dimer complex with Cl- ions [[1qq2]]'> |
| == Function == | | == Function == |
| [[Peroxiredoxin]] (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid hyper oxide forming a Cys-SOH intermediate. A second Cys residue resolves the intermediate to a protein disulfide bond. The Prxs are divided into 3 types according to their intermediate resolving mechanism: '''typical 2-Cysteine Prx''' in which the Cys-Cys bond is formed between two subunits, '''atypical 2-Cys Prx''' in which the bond is formed within one subunit and '''1-Cysteine Prx''' which uses a single Cys residue for the catalysis. | | [[Peroxiredoxin]] (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid hyper oxide forming a Cys-SOH intermediate. A second Cys residue resolves the intermediate to a protein disulfide bond. The Prxs are divided into 3 types according to their intermediate resolving mechanism: '''typical 2-Cysteine Prx''' in which the Cys-Cys bond is formed between two subunits, '''atypical 2-Cys Prx''' in which the bond is formed within one subunit and '''1-Cysteine Prx''' which uses a single Cys residue for the catalysis. '''Prx Q''' is the plant homolog of [[Bacterioferritin comigratory protein]]. |
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| '''Typical 2-Cys Prx'''<br /> | | '''Typical 2-Cys Prx'''<br /> |
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| == Structural highlights == | | == Structural highlights == |
| In the typical 2-cysteine Prx the <scene name='43/433646/Cv/3'>Cys-Cys bond is formed between two subunits</scene><ref>PMID:10535922</ref>. <scene name='43/433646/Cv/4'>Cl coordination site</scene>. | | In the typical 2-cysteine Prx the <scene name='43/433646/Cv/5'>Cys-Cys bond is formed between two subunits</scene><ref>PMID:10535922</ref>. <scene name='43/433646/Cv/6'>Cl coordination site</scene>. Water molecules is shown as red sphere. |
| </StructureSection>
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| == 3D Structures of Peroxiredoxin == | | == 3D Structures of Peroxiredoxin == |
| | [[Peroxiredoxin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Peroxiredoxin
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| **[[1qq2]] – r2Cys-Prx – rat<br />
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| **[[2c0d]] – Pf2Cys-Prx – ''Plasmodium falciparum''<br />
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| **[[1xiy]] – Pf1Cys-Prx<br />
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| **[[1xcc]], [[2h01]], [[3tb2]] - 1Cys-Prx – ''Plasmodium yoelii''<br />
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| **[[2i81]] - 2Cys-Prx – ''Plasmodium vivax''<br />
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| **[[1qmv]] - h2Cys-Prx – human<br />
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| **[[2a4v]] – yPrx dot5 C-terminal (mutant) – yeast<br />
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| **[[3cmi]] – yPrx hyr1 - yeast<br />
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| **[[5ept]] - yPrx tsa2<br />
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| **[[3sbc]] – yPrx tsa1 (mutant)<br />
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| **[[5dvb]] - yPrx tsa2 (mutant)<br />
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| **[[4g2e]] – Prx – ''Sulfolobus tokodaii''<br />
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| **[[4llr]] - 2Cys-Prx – ''Trypanosoma cruzi''<br />
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| **[[1we0]] – Prx – ''Amphibacillus xylanus''<br />
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| **[[2cv4]], [[2cx3]], [[2cx4]] – Prx – ''Aeropyrum pernix''<br />
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| **[[3drn]] – SsPrx – ''Sulfolobus solfataricus''<br />
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| **[[3hjp]] – SsPrx (mutant)<br />
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| **[[3ixr]] – Prx PRXQ (mutant) – ''Xylella fastidiosa''<br />
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| **[[5epf]] - Prx – ''Mycobacterium tuberculosis''<br />
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| *Peroxiredoxin 1
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| **[[4xcs]] - hPrx 1 (mutant) <br />
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| **[[2rii]], [[3hy2]] – hPrx 1 (mutant)+sulfiredoxin 1<br />
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| **[[2z9s]] – rPrx 1 (mutant) <br />
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| **[[4kw6]], [[4fh8]] – Prx 1 – ''Ancylostoma ceylanicum''<br />
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| **[[3zl5]] - mPrx 1 (mutant) – mouse<br />
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| *Peroxiredoxin 2
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| **[[1tp9]] – Prx II – ''Populus trichocarpa''<br />
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| **[[2pwj]] – Prx II – garden pea<br />
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| **[[4dsq]], [[4dsr]], [[4h86]], [[4owy]] – yPrx II<br />
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| **[[4dss]] – yPrx II (mutant) + thioredoxin II<br />
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| *Peroxiredoxin 3
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| **[[1zye]] – Prx III (mutant) – bovine<br />
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| **[[5k1g]], [[5k2i]] - VvPrx III (mutant) – ''Vibrio vulnificus''<br />
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| **[[5k2j]] - VvPrx III (mutant) + H2O2<br />
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| *Peroxiredoxin 4
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| **[[3tjf]], [[3tjg]], [[3tjj]], [[3tjk]], [[3tkr]] - hPrx 4 (mutant)<br />
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| **[[5hqp]] - hPrx 4 (mutant) + ERP44<br />
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| **[[4rqx]] – hPrx 4 + thioethanesulfonic acid<br />
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| **[[3qpm]] – Prx 4 – ''Larimichtys crocea''<br />
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| **[[2pn8]], [[3tjb]], [[3tkp]], [[3tkq]], [[3tks]] – hPrx 4<br />
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| **[[3vwu]], [[3vwv]] - mPrx 4 (mutant) <br />
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| *Peroxiredoxin 5
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| **[[1urm]] – hPrx 5 (mutant) – human<br />
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| **[[2vl2]], [[2vl3]], [[2vl9]], [[1h4o]], [[1hd2]], [[1oc3]] – hPrx 5<br />
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| **[[3mng]] – hPrx 5+DTT<br />
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| **[[4k7i]], [[4k7n]], [[4k7o]], [[4mmm]] – hPrx 5 catalytic domain + fragment<br />
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| **[[2wfc]] – lPrx 5 - lugworm<br />
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| **[[2xhf]] – Prx 5 – ''Alvinella pompejana''<br />
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| *Peroxiredoxin 6
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| **[[2v2g]] – lPrx 6 <br />
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| **[[2v32]], [[2v41]] – lPrx 6 (mutant)<br />
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| **[[5b6m]], [[5b6n]] - hPrx 6<br />
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| *Peroxiredoxin Asp F3
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| **[[5j9b]] – NfPrx – ''Neosartorya fumigata''<br />
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| **[[5j9c]] - NfPrx (mutant) <br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
