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==A STRUCTURAL COMPARISON OF 21 INHIBITOR COMPLEXES OF THE ASPARTIC PROTEINASE FROM ENDOTHIA PARASITICA==
==A STRUCTURAL COMPARISON OF 21 INHIBITOR COMPLEXES OF THE ASPARTIC PROTEINASE FROM ENDOTHIA PARASITICA==
<StructureSection load='1epn' size='340' side='right' caption='[[1epn]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='1epn' size='340' side='right'caption='[[1epn]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1epn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EPN FirstGlance]. <br>
<table><tr><td colspan='2'>[[1epn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EPN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2ZS:N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANYL-N-[(1R,2S)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-3-(1-METHYLETHOXY)-3-OXOPROPYL]-S-METHYL-L-CYSTEINAMIDE'>2ZS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1epl|1epl]], [[1epm|1epm]], [[1epr|1epr]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2ZS:N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANYL-N-[(1R,2S)-1-(CYCLOHEXYLMETHYL)-2-HYDROXY-3-(1-METHYLETHOXY)-3-OXOPROPYL]-S-METHYL-L-CYSTEINAMIDE'>2ZS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1epn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1epn OCA], [https://pdbe.org/1epn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1epn RCSB], [https://www.ebi.ac.uk/pdbsum/1epn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1epn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1epn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1epn OCA], [http://pdbe.org/1epn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1epn RCSB], [http://www.ebi.ac.uk/pdbsum/1epn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1epn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CARP_CRYPA CARP_CRYPA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/1epn_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/1epn_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Endothiapepsin]]
[[Category: Cryphonectria parasitica]]
[[Category: Blundell, T L]]
[[Category: Large Structures]]
[[Category: Cooper, J B]]
[[Category: Blundell TL]]
[[Category: Crawford, M]]
[[Category: Cooper JB]]
[[Category: Acid proteinase]]
[[Category: Crawford M]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
Retrieved from "https://proteopedia.org/1epn"