5aqj: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:


==Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues==
==Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues==
<StructureSection load='5aqj' size='340' side='right' caption='[[5aqj]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
<StructureSection load='5aqj' size='340' side='right'caption='[[5aqj]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5aqj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AQJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5aqj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AQJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=Q88:9H-PURINE-6,8-DIAMINE'>Q88</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aqf|5aqf]], [[5aqg|5aqg]], [[5aqh|5aqh]], [[5aqi|5aqi]], [[5aqk|5aqk]], [[5aql|5aql]], [[5aqm|5aqm]], [[5aqn|5aqn]], [[5aqo|5aqo]], [[5aqp|5aqp]], [[5aqq|5aqq]], [[5aqr|5aqr]], [[5aqs|5aqs]], [[5aqt|5aqt]], [[5aqu|5aqu]], [[5aqv|5aqv]], [[5aqw|5aqw]], [[5aqx|5aqx]], [[5aqy|5aqy]], [[5aqz|5aqz]], [[5ar0|5ar0]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=Q88:9H-PURINE-6,8-DIAMINE'>Q88</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitochondrial_protein-transporting_ATPase Mitochondrial protein-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.51 3.6.3.51] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aqj OCA], [https://pdbe.org/5aqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aqj RCSB], [https://www.ebi.ac.uk/pdbsum/5aqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aqj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aqj OCA], [http://pdbe.org/5aqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aqj RCSB], [http://www.ebi.ac.uk/pdbsum/5aqj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aqj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref>  [[http://www.uniprot.org/uniprot/BAG1_HUMAN BAG1_HUMAN]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9305631</ref> <ref>PMID:9873016</ref> <ref>PMID:12724406</ref>
[https://www.uniprot.org/uniprot/BAG1_HUMAN BAG1_HUMAN] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9305631</ref> <ref>PMID:9873016</ref> <ref>PMID:12724406</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 21:


==See Also==
==See Also==
*[[Heat Shock Proteins|Heat Shock Proteins]]
*[[BAG family proteins 3D structures|BAG family proteins 3D structures]]
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mitochondrial protein-transporting ATPase]]
[[Category: Homo sapiens]]
[[Category: Burke, R]]
[[Category: Large Structures]]
[[Category: Cheeseman, M D]]
[[Category: Burke R]]
[[Category: Collins, I]]
[[Category: Cheeseman MD]]
[[Category: Dobson, S E]]
[[Category: Collins I]]
[[Category: Jeganathan, F]]
[[Category: Dobson SE]]
[[Category: Jones, A M]]
[[Category: Jeganathan F]]
[[Category: Jones, K]]
[[Category: Jones AM]]
[[Category: Kadi, N]]
[[Category: Jones K]]
[[Category: Lee, D]]
[[Category: Kadi N]]
[[Category: Liu, M]]
[[Category: Lee D]]
[[Category: Matthews, T P]]
[[Category: Liu M]]
[[Category: McAndrew, C]]
[[Category: Matthews TP]]
[[Category: Montfort, R L.M van]]
[[Category: McAndrew C]]
[[Category: Osborne, J D]]
[[Category: Osborne JD]]
[[Category: Richards, M]]
[[Category: Richards M]]
[[Category: Rowlands, M G]]
[[Category: Rowlands MG]]
[[Category: Westwood, I M]]
[[Category: Westwood IM]]
[[Category: Workman, P]]
[[Category: Workman P]]
[[Category: Yahya, N]]
[[Category: Yahya N]]
[[Category: Atpase]]
[[Category: Van Montfort RLM]]
[[Category: Bag1]]
[[Category: Chaperone]]
[[Category: Fragment]]
[[Category: Heat shock protein]]
[[Category: Hsc70]]
[[Category: Hsp70]]
[[Category: Hsp72]]
Retrieved from "https://proteopedia.org/5aqj"