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New page: ==The crystal structure of GfsF== <StructureSection load='5y1i' size='340' side='right' caption='5y1i, resolution 2.00Å' scene=''> == Structural highlights == <ta...
 
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==The crystal structure of GfsF==
==The crystal structure of GfsF==
<StructureSection load='5y1i' size='340' side='right' caption='[[5y1i]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='5y1i' size='340' side='right'caption='[[5y1i]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5y1i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y1I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y1I FirstGlance]. <br>
<table><tr><td colspan='2'>[[5y1i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_graminofaciens Streptomyces graminofaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y1I FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y1i OCA], [http://pdbe.org/5y1i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y1i RCSB], [http://www.ebi.ac.uk/pdbsum/5y1i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y1i ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y1i OCA], [https://pdbe.org/5y1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y1i RCSB], [https://www.ebi.ac.uk/pdbsum/5y1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y1i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GFSF_STRHA GFSF_STRHA] Involved in the synthesis of the 16-membered macrolide antibiotics FD-891 and FD-892 (PubMed:20589823, PubMed:26630077, PubMed:28869713). Consecutively catalyzes epoxidation of C8-C9 and then hydroxylation at C10 to convert 25-O-methyl-FD-892 to FD-891 (PubMed:20589823). Consecutively catalyzes epoxidation of C8-C9 and then hydroxylation at C10 to convert 8,9-epoxy-FD-892 to 25-O-demethyl-FD-891 as well as converting 25-oxo-FD-892 to 8,9-epoxy-25-oxo-FD-892 and 8,9-epoxy-10-hydroxy-25-oxo-FD-892 (PubMed:26630077). In vitro is furnished with P.putida putidaredoxin and putidaredoxin reductase to provide the required two-electron reduction (PubMed:20589823, PubMed:26630077, PubMed:28869713).<ref>PMID:20589823</ref> <ref>PMID:26630077</ref> <ref>PMID:28869713</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5y1i" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5y1i" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Eguchi, T]]
[[Category: Large Structures]]
[[Category: Kudo, F]]
[[Category: Streptomyces graminofaciens]]
[[Category: Miyanaga, A]]
[[Category: Eguchi T]]
[[Category: Heme]]
[[Category: Kudo F]]
[[Category: Monooxygenase]]
[[Category: Miyanaga A]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/5y1i"