5co0: Difference between revisions
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==Crystal Structure of the MTERF1 Y288A substitution bound to the termination sequence.== | ==Crystal Structure of the MTERF1 Y288A substitution bound to the termination sequence.== | ||
<StructureSection load='5co0' size='340' side='right' caption='[[5co0]], [[Resolution|resolution]] 2.65Å' scene=''> | <StructureSection load='5co0' size='340' side='right'caption='[[5co0]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5co0]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CO0 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5co0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CO0 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5co0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5co0 OCA], [https://pdbe.org/5co0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5co0 RCSB], [https://www.ebi.ac.uk/pdbsum/5co0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5co0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MTEF1_HUMAN MTEF1_HUMAN] Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.<ref>PMID:20550934</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Byrnes | [[Category: Homo sapiens]] | ||
[[Category: Garcia-Diaz | [[Category: Large Structures]] | ||
[[Category: Hauser | [[Category: Byrnes J]] | ||
[[Category: Mejia | [[Category: Garcia-Diaz M]] | ||
[[Category: Norona | [[Category: Hauser K]] | ||
[[Category: Simmerling | [[Category: Mejia E]] | ||
[[Category: Norona L]] | |||
[[Category: Simmerling C]] | |||
