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==Crystal structure of DpgC with bound substrate analog and Xe on oxygen diffusion pathway==
==Crystal structure of DpgC with bound substrate analog and Xe on oxygen diffusion pathway==
<StructureSection load='4ylh' size='340' side='right' caption='[[4ylh]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
<StructureSection load='4ylh' size='340' side='right'caption='[[4ylh]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ylh]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YLH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YLH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ylh]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_toyocaensis Streptomyces toyocaensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YLH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YLH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XE:XENON'>XE</scene>, <scene name='pdbligand=YE1:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+(3R)-4-({3-[(2-{[(3,5-DIHYDROXYPHENYL)ACETYL]AMINO}ETHYL)AMINO]-3-OXOPROPYL}AMINO)-3-HYDROXY-2,2-DIMETHYL-4-OXOBUTYL+DIHYDROGEN+DIPHOSPHATE'>YE1</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.58&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2np9|2np9]], [[2pg8|2pg8]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XE:XENON'>XE</scene>, <scene name='pdbligand=YE1:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+(3R)-4-({3-[(2-{[(3,5-DIHYDROXYPHENYL)ACETYL]AMINO}ETHYL)AMINO]-3-OXOPROPYL}AMINO)-3-HYDROXY-2,2-DIMETHYL-4-OXOBUTYL+DIHYDROGEN+DIPHOSPHATE'>YE1</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ylh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ylh OCA], [http://pdbe.org/4ylh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ylh RCSB], [http://www.ebi.ac.uk/pdbsum/4ylh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ylh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ylh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ylh OCA], [https://pdbe.org/4ylh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ylh RCSB], [https://www.ebi.ac.uk/pdbsum/4ylh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ylh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPGC_STRTO DPGC_STRTO] Involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. Catalyzes the unusual conversion 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) to 3,5-dihydroxyphenylglyoxylate. DpgC performed a net four-electron oxidation of the benzylic carbon of DPA-CoA and the hydrolysis of the thioester bond to generate free CoA (PubMed:18004875, PubMed:17507985). DpgC has the ability to process a diverse range of substituted phenylacetyl-CoA substrates (PubMed:18004875).<ref>PMID:17507985</ref> <ref>PMID:18004875</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ylh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ylh" style="background-color:#fffaf0;"></div>
==See Also==
*[[Enoyl-CoA hydratase 3D structures|Enoyl-CoA hydratase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bruner, S D]]
[[Category: Large Structures]]
[[Category: Condurso, H L]]
[[Category: Streptomyces toyocaensis]]
[[Category: Li, K]]
[[Category: Bruner SD]]
[[Category: Roitberg, A E]]
[[Category: Condurso HL]]
[[Category: Russo, N V.Di]]
[[Category: Di Russo NV]]
[[Category: Dioxygenase]]
[[Category: Li K]]
[[Category: Hydrolase]]
[[Category: Roitberg AE]]
[[Category: Xe complex]]
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