Response regulator: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
Joel L. Sussman (talk | contribs)
ConfirmAccount, Editor, Mutation, Print3D, Tester, Bureaucrats, journal
11,588 edits
No edit summary
Michal Harel (talk | contribs)
32,831 edits
No edit summary
 
(8 intermediate revisions by 3 users not shown)
Line 1: Line 1:
<StructureSection load='' size='400' side='right' scene='' caption='Se-Met DNA-binding response regulator D complex with thiocyanate, [[1kgs]]'>
<StructureSection load='1kgs' size='350' side='right' scene='' caption='Se-Met DNA-binding response regulator D complex with thiocyanate, [[1kgs]]'>
 
'''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments.
'''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments.
Two-component RR is a complex of histidine kinase (sensor protein SP) and RR.  The RR act as phosphorylation-activated switches.  Most RR consist of N terminal which is the signal receiving domain and C terminal which is the DNA-binding domain (DBD).
Two-component RR is a complex of histidine kinase (sensor protein SP) and RR.  The RR act as phosphorylation-activated switches.  Most RR consist of N terminal which is the signal receiving domain and C terminal which is the DNA-binding domain (DBD).


*'''RR CheY''' is a chemotaxis  response regulator in bacteria<ref>PMID:14563873</ref>. <br />
*'''RR CheY''' is a chemotaxis  response regulator in bacteria see [[Chemotaxis protein]].<ref>PMID:14563873</ref>. <br />
*'''RR Spo0''' is the sporulation response regulator<ref>PMID:12829280</ref>. <br />
*'''RR Spo0''' is the sporulation response regulator<ref>PMID:12829280</ref>. <br />
*'''RR PleD''' is required in loss of motility<ref>PMID:7592388</ref>. For details see [[PleD activation]], [[PleD allosteric product inhibition]], [[PleD catalysis]] and [[Response regulator PLED in complex with C-di-GMP]]<br />
*'''RR PleD''' is required in loss of motility<ref>PMID:7592388</ref>. For details see [[PleD activation]], [[PleD allosteric product inhibition]], [[PleD catalysis]] and [[Response regulator PLED in complex with C-di-GMP]]<br />
Line 11: Line 10:
*'''RR WspR''' couples the chemosensory Wsp pathway to the overproduction of acetylated cellulase <ref>PMID:17379708</ref>. For details see [[WspR]].<br />
*'''RR WspR''' couples the chemosensory Wsp pathway to the overproduction of acetylated cellulase <ref>PMID:17379708</ref>. For details see [[WspR]].<br />
*'''Redox RR''' is DNA-sequence specific.  It controls transcription as a result of its phosphorylation by a redox sensor<ref>PMID:8405457</ref>. <br />
*'''Redox RR''' is DNA-sequence specific.  It controls transcription as a result of its phosphorylation by a redox sensor<ref>PMID:8405457</ref>. <br />
</StructureSection>
== 3D Structures of response regulator ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
For '''iron response regulator Irr''' see [[Irr]].
{{#tree:id=OrganizedByTopic|openlevels=0|


*Nitrate/nitrite response regulator
== 3D Structures of response regulator ==
[[Response regulator 3D structure]]


**[[1rnl]], [[1a04]] – EcNarL – ''Escherichia coli''<br/ >
</StructureSection>
**[[1je8]], [[1zg1]], [[1zg5]] – EcNarL DNA-binding domain + DNA


*Sporulation response regulator
**[[1srr]], [[2jvi]], [[2jvj]], [[2jvk]] – BsSpo0F (mutant) – ''Bacillus subtilis''<br/ >
**[[1nat]] - BsSpo0F<br/ >
**[[3q15]] - BsSpo0F + RR aspartate phosphatase<br/ >
**[[1ixm]] - BsSpo0B<br/ >
**[[1fc3]] – GsSpo0A trans-activation domain – ''Geobacillus stearothermophilus''<br />
**[[1dz3]], [[1qmp]] - GsSpo0A reciever domain
*DNA-binding response regulator
**[[1kgs]] – TmDrrD – ''Thermotoga maritima''<br/ >
**[[3nnn]] – TmDrrD receiver domain + BeF3<BR/ >
**[[1p2f]] – TmDrrB<br/ >
**[[3nns]] - TmDrrB receiver domain + BeF3<BR/ >
**[[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpMicArec receiver domain – ''Streptococcus pneumonia''<br/ >
**[[2gwr]] - MtMtrA – ''Mycobacterium tuberculosis''<br/ >
**[[2hwv]] – EfVicR C terminal – ''Enterococcus faecalis''<br/ >
**[[2qsj]] – LuxR – ''Silicibbacter pomeroyi''<br/ >
**[[3cnb]], [[3eqz]] – MerR receiver domain – ''Colwellia psychrerythraea''<br/ >
**[[2rnj]] – SaVraR DBD – ''Staphylococcus aureus'' – NMR<br/ >
**[[2zxj]] - SaWalR DBD<br/ >
**[[4gvp]] – SaVraR<br />
**[[4if4]] – SaVraR + Mg + BeF3<br />
**[[3q9s]] – DrRR receiver domain – ''Deinococcus radiodurans''<br/ >
**[[3q9v]] - DrRR C terminal<br />
**[[3rjp]] - RR DBD – ''Streptococcus pyogenes''<br />
**[[2a9r]] – SpRR N terminal + phosphate + Mg
*Cyanobacterial phytochrome response regulator
**[[1i3c]] – SyRcp1 – ''Synechocystis''<br/ >
**[[1jlk]] – SyRcp1 + Mn<br/ >
**[[1k66]] – ToRcpB – ''Tolypothrix''<br/ >
**[[1k68]] – ToRcpB
*Phosphatase synthesis response regulator
**[[1mvo]] – BsPhoP receiver domain<br/ >
**[[2jb9]], [[2jba]] – EcPhoB (mutant) <br/ >
**[[2pmu]] – MtPhoP DBD
*Polar differentiation response regulator
**[[1m5t]], [[1m5u]] – CvDivK – ''Caulobacter vibrioides''<br/ >
**[[1mav]], [[1mb0]], [[1mb3]] – CvDivK + cation
*Photosynthetic apparatus response regulator
**[[1umq]] – PrrA DBD – ''Rhodobacter sphaeroides'' – NMR<br/ >
**[[1ys6]] – MtPrrA <br/ >
**[[1ys7]] – MtPrrA + Mg
*Redox response regulator
**[[1xhe]] – EcArcA receiver domain <br/ >
**[[1xhf]] – EcArcA receiver domain + BeF3<BR/ >
**[[4ynr]] - MtDevs GAF domain + CO<br />
**[[4yof]] - MtDevs GAF domain + NO<br />
**[[2y79]] – MtDevs GAF domain (mutant)<br />
**[[3zxo]] - MtDevs ATP-binding domain (mutant)<br />
*Social motility response regulator
**[[2gkg]], [[2i6f]] – MxFrzS receiver domain – ''Myxococcus xanthus'' <br/ >
**[[2nt3]], [[2nt4]] - MxFrzS receiver domain (mutant)
*Stalked-cell differentiation response regulator
**[[2v0n]] – CvPleD + GMP + GTP<br/ >
**[[2wb4]], [[1w25]] - CvPleD + GMP
*Hypoxia response regulator
**[[3c3w]], [[1zlj]] – MtDosR<br/ >
**[[3c57]] – MtDosR C terminal<br />
**[[1zlk]] – MtDosR C terminal + DNA<br />
**[[3zxo]] – MtDost ATP-binding domain<br />
*Transcriptional response regulator
**[[2zwm]] – BsYycF receiver domain<br/ >
**[[5iuj]], [[5iuk]], [[5iul]], [[5iun]] - BsDesR + DesK<br />
**[[3ulq]] – BsComA DBD + RR aspartate phosphatase<br />
**[[2pkx]] – EcPhoP regulatory domain<br />
**[[5ed4]] - MtPhoP + DNA<br />
**[[3nhz]] – MtMtra N terminal<br />
**[[5fmn]] - SyInrS<br />
**[[5lwk]] - LpMaeR + BeF3 - ''Lactobacillus paracasei''<br />
**[[5lwl]] - LpMaeR (mutant)<br />
**[[4g9y]] - ScPcaV - ''Streptomyces coelicolor''<br />
**[[4fht]] - ScPcaV + hydroxybenzoic acid<br />
**[[4u88]] - SaSaeR DBD<br />
**[[4ixa]] - SaeR DBD - ''Staphylococcus epidermidis''<br />
**[[4so5]] - BasR + DNA - ''Klebsiella pneumoniae''<br />
*Stress response regulator
**[[3n0r]] – CVPhyR<br />
**[[5i4c]] - EcRcsB receiver domain<br />
**[[3cra]], [[3crc]] - EcMazG<br />
**[[2v42]], [[2v43]] - EcRseB<br />
*Chemotaxis response regulator see [[Chemotaxix protein]]
*Two-component response regulator
**[[2lpm]] – SmRR <br />
**[[2m98]] – RR – ''Sinorhizobium meliloti''<br />
**[[4q7e]] – RR receiver domain – ''Leptospira biflexa''<br />
**[[2qr3]] – RR N terminal – ''Bacteroides fragilis''<br />
**[[2qzj]] – RR – ''Clostridium difficile''<br />
**[[3cz5]] – RR – ''Aurantimonas''<br />
**[[2qvg]] - RR - ''Legionella pneumophila''<br />
**[[3ilh]] - RR - ''Cytophaga hutchinsonii''<br />
**[[5brj]] - RR - ''Agrobacterium tumefaciens''<br />
**[[5uic]] - QseB - ''Francisella tularensis''<br />
**[[3lsg]] - RR C-terminal - ''Fusobacterium nucleatum''<br />
**[[3p01]] - RR - Nostoc<br />
*response regulator receiver domain protein
**[[4wsz]] – EfRR<br />
**[[3c3m]] – RR – ''Methanoculleus marisnigri''<br/ >
**[[3heb]] - RR – ''Rhodospirillum rubrum''<br/ >
**[[3lte]] – RR – ''Bermanella marisrubri''<br/ >
**[[3jte]], [[3lua]] – RR – ''Clostridium thermocellum''<br />
**[[4wt0]] – EfRR DNA-binding domain (mutant)<br />
**[[4wu4]], [[4wuh]], [[4wul]] – EfRR DNA-binding domain + DNA<br />
**[[4xlt]] – RR – ''Dyadobacter fermentans''<br />
*Unspecified response regulator
**[[1yio]], [[1zn2]] – StyR – ''Pseudomonas fluorescens''<br/ >
**[[3a0u]], [[3a10]] – TmTrrA + Mg + BeF3<BR/ >
**[[2qvg]] – RR – ''Legionella pneumophila''<br/ >
**[[3gl9]], [[2qxy]], [[4ja2]] - TmRR<br/ >
**[[4hye]] – SpRR<br />
**[[2zay]] – RR – ''Desulfuromonas acetoxidans''<br/ >
**[[2rdm]] – RR (mutant) – ''Sinorhizobium medicae''<br/ >
**[[3hdv]] – RR – ''Pseudomonas putida''<br/ >
**[[3i5a]] – PsWspR – ''Pseudomonas syringae''<br/ >
**[[3ilh]] – RR – ''Cytophaga hutchinsonii''<br/ >
**[[3i5b]] – PaWspR GGDEF domain<br/ >
**[[3i5c]] – PaWspR GGDEF domain/GCN4 leucine zipper<br/ >
**[[3ljx]] – McMmoQ – ''Methylococcus capsulatus''<br/ >
**[[3p3q]] – McMmoQ (mutant) <br/ >
**[[3lsg]] – RR C terminal – ''Fusobacterium nucleatum''<br/ >
**[[3nhm]] – MxRR<br/ >
**[[3m6m]] – XcRpfC REC domain + enoyl-CoA hydratase – ''Xanthomonas campestris''<br/ >
**[[3qyy]] – XcRR GGDEF domain + GMP<br/ >
**[[3p01]] – RR residues 134-315 – ''Nostoc''<br/ >
**[[3rqi]] – RR + phosphate + Ca + citrate – ''Burkholderia pseudomallei''<br/ >
**[[3kto]] – RR - ''Pseudoalteromonas atlantica''<br />
**[[3t0y]] – CvRR anti-anti-σ domain + anti-σ factor NEPR<br />
**[[2oqr]] – MtRR Regx3 <br />
**[[3sy8]] – PaRR Rocr <br />
**[[4ixa]] – RR Saer DNA-binding domain – ''Staphylococcus epidermidis''<br />
**[[4ml3]], [[4mld]] – SpRR Rec domain (mutant)<br />
**[[4cbv]] – SpRR (mutant)<br />
**[[2a9o]], [[2a9p]], [[2a9q]] – SpRR + Mn + BeF3<br />
**[[2pln]] – HP1043 – ''Helicobacter pylori''<br />
**[[3kht]] – RR – ''Hahella chejuensis''
*Response regulator complex with histidine kinase
**[[3dge]], [[3dgf]] – TmRR + sensor protein<br/ >
**[[3a0r]] – TmTrrA (mutant) + sensor protein<br />
**[[4jas]], [[4jav]] – TmRR (mutant) + histidine kinase<br />
}}
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]
Retrieved from "https://proteopedia.org/Response_regulator"