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New page: ==Structure of Coxsackievirus A6 (CVA6) virus A-particle== <StructureSection load='5xs4' size='340' side='right' caption='5xs4, resolution 3.10Å' scene=''> == Str...
 
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==Structure of Coxsackievirus A6 (CVA6) virus A-particle==
==Structure of Coxsackievirus A6 (CVA6) virus A-particle==
<StructureSection load='5xs4' size='340' side='right' caption='[[5xs4]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<SX load='5xs4' size='340' side='right' viewer='molstar' caption='[[5xs4]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5xs4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxsackievirus_a6 Coxsackievirus a6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XS4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5xs4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A6 Coxsackievirus A6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XS4 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xs4 OCA], [http://pdbe.org/5xs4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xs4 RCSB], [http://www.ebi.ac.uk/pdbsum/5xs4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xs4 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xs4 OCA], [https://pdbe.org/5xs4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xs4 RCSB], [https://www.ebi.ac.uk/pdbsum/5xs4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xs4 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/A0A0K2BNC7_9ENTO A0A0K2BNC7_9ENTO]
Coxsackievirus A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in children worldwide but no vaccine is available against CVA6 infections. Here, we demonstrate the isolation of two forms of stable CVA6 particles-procapsid and A-particle-with excellent biochemical stability and natural antigenicity to serve as vaccine candidates. Despite the presence (in A-particle) or absence (in procapsid) of capsid-RNA interactions, the two CVA6 particles have essentially identical atomic capsid structures resembling the uncoating intermediates of other enteroviruses. Our near-atomic resolution structure of CVA6 A-particle complexed with a neutralizing antibody maps an immune-dominant neutralizing epitope to the surface loops of VP1. The structure-guided cell-based inhibition studies further demonstrate that these loops could serve as excellent targets for designing anti-CVA6 vaccines.Coxsackievirus A6 (CVA6) causes hand, foot and mouth disease in children. Here the authors present the CVA6 procapsid and A-particle cryo-EM structures and identify an immune-dominant neutralizing epitope, which can be exploited for vaccine development.
 
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody.,Xu L, Zheng Q, Li S, He M, Wu Y, Li Y, Zhu R, Yu H, Hong Q, Jiang J, Li Z, Li S, Zhao H, Yang L, Hou W, Wang W, Ye X, Zhang J, Baker TS, Cheng T, Zhou ZH, Yan X, Xia N Nat Commun. 2017 Sep 11;8(1):505. doi: 10.1038/s41467-017-00477-9. PMID:28894095<ref>PMID:28894095</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5xs4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Coxsackievirus a6]]
[[Category: Coxsackievirus A6]]
[[Category: Cheng, T]]
[[Category: Large Structures]]
[[Category: He, M Z]]
[[Category: Cheng T]]
[[Category: Li, S W]]
[[Category: He MZ]]
[[Category: Xu, L F]]
[[Category: Li SW]]
[[Category: Yu, H]]
[[Category: Xu LF]]
[[Category: Zheng, Q B]]
[[Category: Yu H]]
[[Category: A-particle]]
[[Category: Zheng QB]]
[[Category: Icosahedral]]
[[Category: Virus]]

Latest revision as of 10:20, 27 March 2024

Structure of Coxsackievirus A6 (CVA6) virus A-particle

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