5v5v: Difference between revisions

<StructureSection load='5v5v' size='340' side='right'caption='[[5v5v]], [[Resolution|resolution]] 4.11&Aring;' scene=''>

<table><tr><td colspan='2'>[[5v5v]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V5V FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.11&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5v OCA], [https://pdbe.org/5v5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v5v RCSB], [https://www.ebi.ac.uk/pdbsum/5v5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5v ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/NLGN2_RAT NLGN2_RAT] Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion.<ref>PMID:19755106</ref> <ref>PMID:22528485</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Rattus norvegicus]]

[[Category: Gangwar SP]]

[[Category: Machius M]]

[[Category: Rudenko G]]