5o4d: Difference between revisions
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New page: '''Unreleased structure''' The entry 5o4d is ON HOLD Authors: Description: Category: Unreleased Structures |
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The | ==G-quadruplex of Human papillomavirus type 52== | ||
<StructureSection load='5o4d' size='340' side='right'caption='[[5o4d]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5o4d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_52 Human papillomavirus 52]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O4D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o4d OCA], [https://pdbe.org/5o4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o4d RCSB], [https://www.ebi.ac.uk/pdbsum/5o4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o4d ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The potential to affect gene expression via G-quadruplex stabilization has been extended to all domains of life, including viruses. Here, we investigate the polymorphism and structures of G-quadruplexes of the human papillomavirus type 52 with UV, CD and NMR spectroscopy and gel electrophoresis. We show that oligonucleotide with five G-tracts folds into several structures and that naturally occurring single nucleotide polymorphisms (SNPs) have profound effects on the structural polymorphism in the context of G-quadruplex forming propensity, conformational heterogeneity and folding stability. With help of SNP analysis, we were able to select one of the predominant forms, formed by G-rich sequence d(G(3)TAG(3)CAG(4)ACACAG(3)T). This oligonucleotide termed HPV52(1-4) adopts a three G-quartet snap back (3 + 1) type scaffold with four syn guanine residues, two edgewise loops spanning the same groove, a no-residue V loop and a propeller type loop. The first guanine residue is incorporated in the central G-quartet and all four-guanine residues from G4 stretch are included in the three quartet G-quadruplex core. Modification studies identified several structural elements that are important for stabilization of the described G-quadruplex fold. Our results expand set of G-rich targets in viral genomes and address the fundamental questions regarding folding of G-rich sequences. | |||
Towards Understanding of Polymorphism of the G-rich Region of Human Papillomavirus Type 52.,Marusic M, Plavec J Molecules. 2019 Apr 2;24(7). pii: molecules24071294. doi:, 10.3390/molecules24071294. PMID:30987050<ref>PMID:30987050</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5o4d" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human papillomavirus 52]] | |||
[[Category: Large Structures]] | |||
[[Category: Marusic M]] | |||
[[Category: Plavec J]] | |||
Latest revision as of 19:07, 29 November 2023
G-quadruplex of Human papillomavirus type 52
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