5opt: Difference between revisions
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The | ==Structure of KSRP in context of Trypanosoma cruzi 40S== | ||
<SX load='5opt' size='340' side='right' viewer='molstar' caption='[[5opt]], [[Resolution|resolution]] 4.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5opt]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OPT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5opt OCA], [https://pdbe.org/5opt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5opt RCSB], [https://www.ebi.ac.uk/pdbsum/5opt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5opt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q4CXR4_TRYCC Q4CXR4_TRYCC] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Kinetoplastids are potentially lethal protozoan pathogens affecting more than 20 million people worldwide. There is a critical need for more specific targets for the development of safer anti-kinetoplastid therapeutic molecules that can replace the scarce and highly cytotoxic current drugs. The kinetoplastid ribosome represents a potential therapeutic target due to its relative structural divergence when compared with its human counterpart. However, several kinetoplastid-specific ribosomal features remain uncharacterized. Here, we present the near-atomic cryoelectron microscopy structure of a novel bona fide kinetoplastid-specific ribosomal (r-) protein (KSRP) bound to the ribosome. KSRP is an essential protein located at the solvent face of the 40S subunit, where it binds and stabilizes kinetoplastid-specific domains of rRNA, suggesting its role in ribosome integrity. KSRP also interacts with the r-protein eS6 at a region that is only conserved in kinetoplastids. The kinetoplastid-specific ribosomal environment of KSRP provides a promising target for the design of safer anti-kinetoplastidian drugs. | |||
The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.,Brito Querido J, Mancera-Martinez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y Structure. 2017 Oct 13. pii: S0969-2126(17)30305-2. doi:, 10.1016/j.str.2017.09.014. PMID:29107485<ref>PMID:29107485</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5opt" style="background-color:#fffaf0;"></div> | ||
[[Category: | |||
[[Category: | ==See Also== | ||
[[Category: | *[[Ribosome 3D structures|Ribosome 3D structures]] | ||
[[Category: | == References == | ||
[[Category: Mancera-Martinez | <references/> | ||
[[Category: Simonetti | __TOC__ | ||
</SX> | |||
[[Category: Large Structures]] | |||
[[Category: Trypanosoma cruzi strain CL Brener]] | |||
[[Category: Bochler A]] | |||
[[Category: Brito Querido J]] | |||
[[Category: Chicher J]] | |||
[[Category: Hashem Y]] | |||
[[Category: Mancera-Martinez E]] | |||
[[Category: Simonetti A]] | |||
[[Category: Vicens Q]] | |||
Latest revision as of 04:33, 21 November 2024
Structure of KSRP in context of Trypanosoma cruzi 40S
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