5uoe: Difference between revisions

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'''Unreleased structure'''


The entry 5uoe is ON HOLD  until Jan 31 2019
==Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)==
<StructureSection load='5uoe' size='340' side='right'caption='[[5uoe]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5uoe]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UOE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uoe OCA], [https://pdbe.org/5uoe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uoe RCSB], [https://www.ebi.ac.uk/pdbsum/5uoe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uoe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>


Authors: Liang, W.G., Bailey, L., Kossiakoff, T., Tang, W.J.
==See Also==
 
*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
Description: Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Liang, W.G]]
__TOC__
[[Category: Tang, W.J]]
</StructureSection>
[[Category: Kossiakoff, T]]
[[Category: Homo sapiens]]
[[Category: Bailey, L]]
[[Category: Large Structures]]
[[Category: Bailey L]]
[[Category: Kossiakoff T]]
[[Category: Liang WG]]
[[Category: Tang WJ]]
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