5w4r: Difference between revisions
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New page: '''Unreleased structure''' The entry 5w4r is ON HOLD Authors: Spurlino, J. Description: Structure of RORgt bound to a tertiary alcohol Category: Unreleased Structures [[Category: S... |
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==Structure of RORgt bound to a tertiary alcohol== | |||
<StructureSection load='5w4r' size='340' side='right'caption='[[5w4r]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5w4r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W4R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.002Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9WD:1-{4-[(R)-(4-chloro-2-methoxy-3-{[4-(1H-pyrazol-1-yl)phenyl]methyl}quinolin-6-yl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]piperidin-1-yl}ethan-1-one'>9WD</scene></td></tr> | ||
[[Category: Spurlino | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w4r OCA], [https://pdbe.org/5w4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w4r RCSB], [https://www.ebi.ac.uk/pdbsum/5w4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w4r ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Spurlino J]] | |||
Latest revision as of 14:13, 13 March 2024
Structure of RORgt bound to a tertiary alcohol
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