5wop: Difference between revisions
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New page: '''Unreleased structure''' The entry 5wop is ON HOLD until Paper Publication Authors: Constantinides, A.E., Gumpper, R.H., Severin, C., Luo, M. Description: High Resolution Structure o... |
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==High Resolution Structure of Mutant CA09-PB2cap== | |||
<StructureSection load='5wop' size='340' side='right'caption='[[5wop]], [[Resolution|resolution]] 1.52Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5wop]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WOP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wop OCA], [https://pdbe.org/5wop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wop RCSB], [https://www.ebi.ac.uk/pdbsum/5wop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wop ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/F4MEU3_9INFA F4MEU3_9INFA] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
In the face of increasing drug resistance and the rapidly increasing necessity for practicality in clinical settings, drugs targeting different viral proteins are needed in order to control influenza A and B. A small molecule that tenaciously adheres to the PB2cap binding domain, part of the heterotrimeric RNA polymerase machinery of influenza A virus and influenza B virus, is a promising drug candidate. Understanding the anatomic behavior of PB2cap upon ligand binding will aid in the development of a more robust inhibitor. In this report, the anatomic behavior of the influenza A virus PB2cap domain is established by solving the crystal structure of native influenza A virus PB2cap at 1.52 A resolution. By comparing it with the ligand-bound structure, the dissociation and rotation of the ligand-binding domain in PB2cap from the C-terminal domain is identified. This domain movement is present in many PB2cap structures, suggesting its functional relevance for polymerase activity. | |||
High-resolution structure of the Influenza A virus PB2cap binding domain illuminates the changes induced by ligand binding.,Constantinides A, Gumpper R, Severin C, Luo M Acta Crystallogr F Struct Biol Commun. 2018 Mar 1;74(Pt 3):122-127. doi:, 10.1107/S2053230X18000894. Epub 2018 Feb 26. PMID:29497014<ref>PMID:29497014</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5wop" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Influenza A virus]] | |||
[[Category: Large Structures]] | |||
[[Category: Constantinides AE]] | |||
[[Category: Gumpper RH]] | |||
[[Category: Luo M]] | |||
[[Category: Severin C]] | |||
Latest revision as of 14:18, 4 October 2023
High Resolution Structure of Mutant CA09-PB2cap
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