5xxd: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5xxd is ~~ON HOLD until Paper Publication~~

==Crystal structure of SmyD3 in complex with covalent inhibitor 1==

== Structural highlights ==

<table><tr><td colspan='2'>[[5xxd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXD OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5XXD FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.314Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8NR:ethyl+4-(5,6,7,8-tetrahydroacridin-3-ylcarbonyl)piperazine-1-carboxylate'>8NR</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5xxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxd OCA], [https://pdbe.org/5xxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xxd RCSB], [https://www.ebi.ac.uk/pdbsum/5xxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxd ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref>

~~Authors~~:

==See Also==

*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]

~~Description~~:

== References ==

[[Category: ~~Unreleased Structures~~]]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Anna E J]]

[[Category: Baburajendran N]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5xxd is ON HOLD  until Paper Publication
+==Crystal structure of SmyD3 in complex with covalent inhibitor 1==
+<StructureSection load='5xxd' size='340' side='right'caption='[[5xxd]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5xxd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XXD FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.314&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8NR:ethyl+4-(5,6,7,8-tetrahydroacridin-3-ylcarbonyl)piperazine-1-carboxylate'>8NR</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxd OCA], [https://pdbe.org/5xxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xxd RCSB], [https://www.ebi.ac.uk/pdbsum/5xxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref>
-Authors:
+==See Also==
+*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Anna E J]]
+[[Category: Baburajendran N]]