5xze: Difference between revisions
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New page: '''Unreleased structure''' The entry 5xze is ON HOLD until Paper Publication Authors: Vincent, J., Adura, C., Gao, P., Luz, A., Lama, L., Asano, Y., Okamoto, R., Imaeda, T., Aida, J., R... |
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==Mouse cGAS bound to the inhibitor RU332== | |||
<StructureSection load='5xze' size='340' side='right'caption='[[5xze]], [[Resolution|resolution]] 2.18Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5xze]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XZE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.177Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AE7:(3R)-3-[1-(3H-1lambda~4~,3-benzothiazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-one'>AE7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xze OCA], [https://pdbe.org/5xze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xze RCSB], [https://www.ebi.ac.uk/pdbsum/5xze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xze ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. | |||
==See Also== | |||
*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Aida | [[Category: Adura C]] | ||
[[Category: | [[Category: Aida J]] | ||
[[Category: | [[Category: Asano Y]] | ||
[[Category: | [[Category: Ascano M]] | ||
[[Category: | [[Category: Aso K]] | ||
[[Category: | [[Category: Gao P]] | ||
[[Category: | [[Category: Glickman JF]] | ||
[[Category: | [[Category: Gogakos T]] | ||
[[Category: | [[Category: Imaeda T]] | ||
[[Category: | [[Category: Lama L]] | ||
[[Category: | [[Category: Luz A]] | ||
[[Category: | [[Category: Okamoto R]] | ||
[[Category: | [[Category: Patel DJ]] | ||
[[Category: Steinberg | [[Category: Reasoner S]] | ||
[[Category: | [[Category: Rothamel K]] | ||
[[Category: | [[Category: Steinberg J]] | ||
[[Category: Tuschl T]] | |||
[[Category: Vincent J]] | |||
Latest revision as of 14:16, 13 March 2024
Mouse cGAS bound to the inhibitor RU332
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