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[[Image:1xru.gif|left|200px]]


{{Structure
==Crystal Structure of 5-keto-4-deoxyuronate Isomerase from Eschericia coli==
|PDB= 1xru |SIZE=350|CAPTION= <scene name='initialview01'>1xru</scene>, resolution 1.94&Aring;
<StructureSection load='1xru' size='340' side='right'caption='[[1xru]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[1xru]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XRU FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/4-deoxy-L-threo-5-hexosulose-uronate_ketol-isomerase 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.17 5.3.1.17] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
|GENE= kduI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xru OCA], [https://pdbe.org/1xru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xru RCSB], [https://www.ebi.ac.uk/pdbsum/1xru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xru ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xru OCA], [http://www.ebi.ac.uk/pdbsum/1xru PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xru RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/KDUI_ECOLI KDUI_ECOLI] Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity).[HAMAP-Rule:MF_00687]
 
== Evolutionary Conservation ==
'''Crystal Structure of 5-keto-4-deoxyuronate Isomerase from Eschericia coli'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xr/1xru_consurf.spt"</scriptWhenChecked>
1XRU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XRU OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==Reference==
  </jmolCheckbox>
The crystal structure of 5-keto-4-deoxyuronate isomerase from Escherichia coli., Crowther RL, Georgiadis MM, Proteins. 2005 Nov 15;61(3):680-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16152643 16152643]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xru ConSurf].
[[Category: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase]]
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Crowther, R L.]]
[[Category: Crowther RL]]
[[Category: Georgiadis, M M.]]
[[Category: Georgiadis MM]]
[[Category: beta barrel]]
[[Category: cupin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:53:45 2008''

Latest revision as of 07:57, 15 May 2024

Crystal Structure of 5-keto-4-deoxyuronate Isomerase from Eschericia coli

1xru, resolution 1.94Å

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