6avq: Difference between revisions
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New page: '''Unreleased structure''' The entry 6avq is ON HOLD Authors: Borst, A.J., James, Z.N., Zagotta, W.N., Ginsberg, M., Rey, F.A., DiMaio, F., Backovic, M., Veesler, D. Description: The T... |
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The | ==The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance== | ||
<SX load='6avq' size='340' side='right' viewer='molstar' caption='[[6avq]], [[Resolution|resolution]] 35.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6avq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AVQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 35Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6avq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6avq OCA], [https://pdbe.org/6avq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6avq RCSB], [https://www.ebi.ac.uk/pdbsum/6avq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6avq ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ITAV_HUMAN ITAV_HUMAN] The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. | |||
==See Also== | |||
*[[Antibody 3D structures|Antibody 3D structures]] | |||
*[[Integrin 3D structures|Integrin 3D structures]] | |||
[[Category: | __TOC__ | ||
[[Category: | </SX> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Ginsberg | [[Category: Backovic M]] | ||
[[Category: | [[Category: Borst AJ]] | ||
[[Category: Rey | [[Category: DiMaio F]] | ||
[[Category: | [[Category: Ginsberg M]] | ||
[[Category: James ZN]] | |||
[[Category: Rey FA]] | |||
[[Category: Veesler D]] | |||
[[Category: Zagotta WN]] | |||
Latest revision as of 14:18, 13 March 2024
The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance
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