6b0z: Difference between revisions

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New page: '''Unreleased structure''' The entry 6b0z is ON HOLD Authors: Xie, X., Kulathila, R. Description: IDH1 R132H mutant in complex with IDH305 Category: Unreleased Structures [[Categor...
 
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'''Unreleased structure'''


The entry 6b0z is ON HOLD
==IDH1 R132H mutant in complex with IDH305==
<StructureSection load='6b0z' size='340' side='right'caption='[[6b0z]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6b0z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B0Z FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.334&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C81:(4R)-4-[(1S)-1-fluoroethyl]-3-[2-({(1S)-1-[4-methyl-2-(trifluoromethyl)[3,4-bipyridin]-6-yl]ethyl}amino)pyrimidin-4-yl]-1,3-oxazolidin-2-one'>C81</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b0z OCA], [https://pdbe.org/6b0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b0z RCSB], [https://www.ebi.ac.uk/pdbsum/6b0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b0z ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/IDHC_HUMAN IDHC_HUMAN] Defects in IDH1 are involved in the development of glioma (GLM) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.
== Function ==
[https://www.uniprot.org/uniprot/IDHC_HUMAN IDHC_HUMAN]


Authors: Xie, X., Kulathila, R.
==See Also==
 
*[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]]
Description: IDH1 R132H mutant in complex with IDH305
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Xie, X]]
[[Category: Homo sapiens]]
[[Category: Kulathila, R]]
[[Category: Large Structures]]
[[Category: Kulathila R]]
[[Category: Xie X]]
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