Journal:FEBS Open Bio:2: Difference between revisions
From Proteopedia
No edit summary |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 18: | Line 18: | ||
Ligand binding at each site appeared to be largely determined through hydrophobic interactions. The crystallographic studies support previous conclusions made on ligand binding in noncatalytic sites by ''At''GSTF2 based on isothermal calorimetry experiments (Dixon ''et al''. (2011)<ref>pmid 21631432 </ref>) and suggest a mode of ligand binding in GSTs commensurate with a possible role in ligand transport. | Ligand binding at each site appeared to be largely determined through hydrophobic interactions. The crystallographic studies support previous conclusions made on ligand binding in noncatalytic sites by ''At''GSTF2 based on isothermal calorimetry experiments (Dixon ''et al''. (2011)<ref>pmid 21631432 </ref>) and suggest a mode of ligand binding in GSTs commensurate with a possible role in ligand transport. | ||
Electrostatic surface views of AtGSTF2: | Electrostatic surface views of AtGSTF2 ({{Template:ColorKey_Charge_Anionic}} / {{Template:ColorKey_Charge_Cationic}} / <font color='powderblue'><b>Histidine (+)</b></font> / White Neutral): | ||
*<scene name='76/763766/Cv1/23'>Same view as in scene with complex with two molecules of S-hexyl glutathione</scene> ([[1gnw]]). | *<scene name='76/763766/Cv1/23'>Same view as in scene with complex with two molecules of S-hexyl glutathione</scene> ([[1gnw]]). | ||
*<scene name='76/763766/Cv1/26'>In complex with quercetrin 3, rotated 90°, and revealing ligand-binding site L1</scene> ([[5a4w]]). | *<scene name='76/763766/Cv1/26'>In complex with quercetrin 3, rotated 90°, and revealing ligand-binding site L1</scene> ([[5a4w]]). | ||
*<scene name='76/763766/Cv1/27'>In complex with quercetrin 3, rotated 180°, and revealing ligand-binding site L2</scene> ([[5a4w]]). | *<scene name='76/763766/Cv1/27'>In complex with quercetrin 3, rotated 180°, and revealing ligand-binding site L2</scene> ([[5a4w]]). | ||
Ligand binding in the L1 site: | Ligand binding in the L1 site: | ||
| Line 40: | Line 38: | ||
*<scene name='76/763766/Cv2/23'>Click here to see summary animation how different ligands bind in the L1 site</scene>. | *<scene name='76/763766/Cv2/23'>Click here to see summary animation how different ligands bind in the L1 site</scene>. | ||
{{Button Toggle AnimationOnPause}}<br/> | {{Button Toggle AnimationOnPause}}<br/> | ||
'''PDB reference:''' AtGSTF2 from ''Arabidopsis thaliana'' in complex with indole-3-aldehyde, [[5a4u]]; AtGSTF2 from ''Arabidopsis thaliana'' in complex with quercetin, [[5a4v]]; AtGSTF2 from ''Arabidopsis thaliana'' in complex with quercetrin, [[5a4w]]; AtGSTF2 from Arabidopsis thaliana in complex with camalexin, [[5a5k]]. | |||
</StructureSection> | </StructureSection> | ||
This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For additional details please see I3DC.
